Clinical Significance of Monitoring Plasma Levels of Psychotropic Drugs

2008 ◽  
pp. 115-139 ◽  
Author(s):  
Paolo Lucio Morselli ◽  
Edouard Zarifian
Keyword(s):  
Clinical Significance ◽  
Psychotropic Drugs ◽  
Plasma Levels

Neuroblastoma and bone metastases: Clinical significance and prognostic value of Dickkopf 1 plasma levels

Bone ◽  
2011 ◽  
Vol 48 (1) ◽  
pp. 152-159 ◽  
Author(s):  
Donatella Granchi ◽  
Maria Valeria Corrias ◽  
Alberto Garaventa ◽  
Serena Rubina Baglìo ◽  
Giuliana Cangemi ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Clinical Significance ◽  
Plasma Levels ◽  
Prognostic Value ◽  
Dickkopf 1

scholarly journals The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs

2002 ◽  
Vol 7 (10) ◽  
pp. 1107-1114 ◽  
Author(s):  
Y-K Kim ◽  
I-B Suh ◽  
H Kim ◽  
C-S Han ◽  
C-S Lim ◽  
...  
Keyword(s):  
Major Depression ◽  
Psychotropic Drugs ◽  
Plasma Levels ◽  
Interleukin 12 ◽  
Bipolar Mania

CLINICAL SIGNIFICANCE OF PLASMA LEVELS OF TRICYCLIC ANTIDEPRESSANT DRUGS IN THE TREATMENT OF DEPRESSION

The Lancet ◽  
1973 ◽  
Vol 301 (7802) ◽  
pp. 556-558 ◽  
Author(s):  
R.A. Braithwaite ◽  
R. Goulding ◽  
G. Theano ◽  
J. Bailey ◽  
A. Coppen ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Plasma Levels ◽  
Antidepressant Drugs ◽  
Tricyclic Antidepressant ◽  
Tricyclic Antidepressant Drugs ◽  
Treatment Of Depression

Capillary Fragility Induced By Psychotropic Serotonergic Drugs

1981 ◽  
Author(s):  
D Shepro ◽  
H B Hechtman
Keyword(s):  
Psychotropic Drugs ◽  
Plasma Levels ◽  
Adrenergic Receptors ◽  
Structural Integrity ◽  
Single Injection ◽  
Biologically Active ◽  
Daily Injection ◽  
Cutaneous Microcirculation ◽  
5 Ht Uptake ◽  
Serotonergic Drugs

In defining a mechanism for the putative platelet support of microvascular structural integrity, we have shown that serotonin (5-HT) injected into thrombocytopenic animals prevents petechial formation for as long as 6 h, and that psychomotor drugs inhibit this palliative action. Our data suggest that a platelet’s role is to deliver- release 5-HT into the cutaneous microcirculation in amounts physiologically above plasma levels, which acts as a signal to maintain “endothelial tone”. In this study psychotropic drugs known to inhibit 5-HT uptake, such as imipramine, amitriptyline, fluoxetine, were studied for their effect on endothelial structural integrity in normal adult hamsters. Adrenergic receptors, inhibitors and catecholamines were also used in conjunction with psychotropic drugs. Bleeding times and plasma levels of 5-HT were quantitated. Following a single injection or daily injection for 21 days of all substances tested, petechial sensitivity increased significantly in normal hamsters. Norepinephrine decreased and propanolol enhanced petechial formation. Microhemorrhages were observed within 5 min post-injection with fluoxetine (4.5 × 10-3 mg⋅100 g-1) and with amitriptyline (0.04 mg.100 g-1). Petechiae occurred for one week following a single injection of fluoxetine, which indicates that the stable metabolite of this antidepressant is biologically active. All other parameters measured were normal except bleeding times, which increased three-fold compared to controls. In published reports, 5-HT has been shown to alter microfilament orientation, especially at junctions. Based upon this observation and the present data, we theorize that the blockade of a 5-HT signal by the uptake antagonist effects endothelial cytoskeletal support of junctions.

Age effect on the plasma levels of various psychotropic drugs

1996 ◽  
Vol 6 ◽  
pp. 36
Author(s):  
M. Kamimura ◽  
N. Yamaguchi ◽  
Y. Morokawa ◽  
T. Ohata ◽  
H. Fujimaki ◽  
...  
Keyword(s):  
Psychotropic Drugs ◽  
Plasma Levels ◽  
Age Effect

The Effect of Orlistat on Plasma Levels of Psychotropic Drugs in Patients With Long-term Psychopharmacotherapy

2002 ◽  
Vol 22 (1) ◽  
pp. 68-70 ◽  
Author(s):  
E. Hilger ◽  
S. Quiner ◽  
I. Ginzel ◽  
H. Walter ◽  
L. Saria ◽  
...  
Keyword(s):  
Psychotropic Drugs ◽  
Plasma Levels

scholarly journals Clinical Significance of Plasma Levels of Soluble CD40 in Patients with Chronic Lymphocytic Leukemia

2013 ◽  
Vol 03 (01) ◽  
pp. 1-5 ◽  
Author(s):  
Barry D. Hock ◽  
Liam J. Fernyhough ◽  
Sheryl M. Gough ◽  
Judith L. McKenzie
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Clinical Significance ◽  
Plasma Levels ◽  
Lymphocytic Leukemia
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