Some Experimental Observations on a Strain of Transmissible Aleukæmic Leukæmia (RPL 12 Lymphoid Tumour)

Author(s):  
C. le Q. Darcel ◽  
G. Negroni
Keyword(s):  
PLoS Genetics ◽  
2016 ◽  
Vol 12 (3) ◽  
pp. e1005945 ◽  
Author(s):  
Philip J. Byrd ◽  
Grant. S. Stewart ◽  
Anna Smith ◽  
Charlotte Eaton ◽  
Alexander J. Taylor ◽  
...  

2011 ◽  
Vol 11 (1) ◽  
pp. 30-50 ◽  
Author(s):  
E. L. Seiser ◽  
R. Thomas ◽  
K. L. Richards ◽  
M. Kathryn Kelley ◽  
P. Moore ◽  
...  

Medicina ◽  
2022 ◽  
Vol 58 (1) ◽  
pp. 106
Author(s):  
Cristina Capsa ◽  
Laura Aifer Calustian ◽  
Sabina Antonela Antoniu ◽  
Eugen Bratucu ◽  
Laurentiu Simion ◽  
...  

Introduction: Non-Hodgkin lymphomas (NHL) comprise 85% of the total lymphomas diagnosed, with the histological type of diffuse large B-cell lymphomas (DLBCL) being the most prevalent in adults. In about 40% of cases, the location is extranodal. Uterine cervix lymphomas of this type are extremely rare (0.5–1.5%) and represent a diagnostic challenge. A case of DLBCL of the cervix is presented here along with a review of the literature. Materials and methods: A 75-year-old patient was referred with a bleeding vegetant tumour occupying her entire vagina. The histological and pathological investigations performed following the tumour biopsy indicated a malignant, diffuse, vaguely nodular lymphoid tumour proliferation. The immunohistochemistry results were in favour of a diffuse B-cell non-Hodgkin lymphoma (DLBCL). CHOP (Cyclophosphamide, Hydroxydaunorubicin (also called doxorubicin or adriamycin), Oncovin (vincristine), Prednisone or Prednisolone) polychemotherapy and radiotherapy were effective and resulted in tumour regression (from 3.4 cm to tumour disappearance, with the cervix returning to normal size). Conclusions: The uterine cervix lymphoma prognosis is more conservative than that for a nodal lymphoma, mainly due to a later diagnosis determined via immunohistochemistry. Chemotherapy is the main treatment.


2018 ◽  
Author(s):  
Hajime Asada ◽  
Hirotaka Tomiyasu ◽  
Takao Uchikai ◽  
Genki Ishihara ◽  
Yuko Goto-Koshino ◽  
...  

AbstractExosomes are small extracellular vesicles released from almost all cell types, which play roles in cell-cell communication. Recent studies have suggested that microenvironmental crosstalk mediated by exosomes is an important factor in the escape of tumour cells from the anti-tumour immune system in human haematopoietic malignancies. Here, we conducted comprehensive analysis of the miRNA and protein profiles within the exosomes released from four canine lymphoid tumour cell lines as a model of human lymphoid tumours. The results showed that the miRNAs and proteins abundantly contained in exosomes were similar among the four cell lines. However, the profiles of miRNA within exosomes differed among the cell lines and reflected the expression pattern of miRNAs of the parent cells. In the comparison of the amounts of miRNAs and proteins among the cell lines, those of three miRNAs (miR-151, miR-8908a-3p, and miR-486) and CD82 protein differed between exosomes derived from vincristine-sensitive and resistant cell lines. Further investigations are needed to elucidate the biological functions of the exosomal contents in the microenvironmental crosstalk of lymphoid tumours.


Author(s):  
D. J. Moss ◽  
J. A. Staples ◽  
S. R. Burrows ◽  
J. Ryan ◽  
T. B. Sculley

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0208567 ◽  
Author(s):  
Hajime Asada ◽  
Hirotaka Tomiyasu ◽  
Takao Uchikai ◽  
Genki Ishihara ◽  
Yuko Goto-Koshino ◽  
...  

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