Chirality and Dipolar Interactions of Membrane Mimetic Amphiphilic Molecules

Author(s):  
Nilashis Nandi ◽  
K. Thirumoorthy ◽  
Dieter Vollhardt
Author(s):  
Keith J. Stine

Understanding the organization of amphiphilic molecules at interfaces is of fundamental importance in a number of fields of research. Langmuir-Blodgett technology and membrane mimetic chemistry are based on understanding the structural and physical properties of monolayers of amphiphilic compounds. This is a challenging area with numerous unresolved questions. For example, monolayers of amphiphilic compounds as simple as long-chain fatty acids and esters exhibit complex phase behavior which is still under investigation. In order to investigate biomembrane structure and processes, model systems can be constructed. Monolayers of phospholipids at the air/water interface serve as membrane models and have been used to investigate the effects of varying temperature, surface density, and subphase conditions. Study of the interaction of a protein introduced into the subphase with the monolayer can provide insight into a specific membrane process. In this review, fluorescence microscopy studies by a number of research groups of monolayers of fatty acids and esters, phospholipids, and of interactions of proteins with phospholipid monolayers will be discussed.


1985 ◽  
Vol 46 (C6) ◽  
pp. C6-283-C6-286
Author(s):  
A. Bradbury ◽  
S. Menear ◽  
R. W. Chantrell ◽  
K. O'Grady

2000 ◽  
Vol 653 ◽  
Author(s):  
Celeste Sagui ◽  
Thoma Darden

AbstractFixed and induced point dipoles have been implemented in the Ewald and Particle-Mesh Ewald (PME) formalisms. During molecular dynamics (MD) the induced dipoles can be propagated along with the atomic positions either by interation to self-consistency at each time step, or by a Car-Parrinello (CP) technique using an extended Lagrangian formalism. The use of PME for electrostatics of fixed charges and induced dipoles together with a CP treatment of dipole propagation in MD simulations leads to a cost overhead of only 33% above that of MD simulations using standard PME with fixed charges, allowing the study of polarizability in largemacromolecular systems.


2020 ◽  
Vol 65 (9) ◽  
pp. 1475-1483
Author(s):  
S. A. Alekseeva ◽  
I. V. Baranets ◽  
V. N. Beresnev ◽  
T. A. Nadervel ◽  
A. D. Kryuchkov ◽  
...  

2021 ◽  
Vol 126 (13) ◽  
Author(s):  
D. G. Suárez-Forero ◽  
F. Riminucci ◽  
V. Ardizzone ◽  
N. Karpowicz ◽  
E. Maggiolini ◽  
...  

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