Exploring Stem Cell Biology with Small Molecules and Functional Genomics

2008 ◽  
pp. 187-206 ◽  
Author(s):  
Julie Clark ◽  
Yue Xu ◽  
Simon Hilcove ◽  
Sheng Ding
Keyword(s):  
Stem Cell ◽  
Functional Genomics ◽  
Small Molecules ◽  
Cell Biology ◽  
Stem Cell Biology

scholarly journals The evolving biology of small molecules: controlling cell fate and identity

2011 ◽  
Vol 366 (1575) ◽  
pp. 2208-2221 ◽  
Author(s):  
Jem A. Efe ◽  
Sheng Ding
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Small Molecules ◽  
Somatic Cell ◽  
Cell Fate ◽  
Cell Biology ◽  
Adult Stem Cells ◽  
Stem Cell Biology ◽  
Vast Number ◽  
Short Period

Small molecules have been playing important roles in elucidating basic biology and treatment of a vast number of diseases for nearly a century, making their use in the field of stem cell biology a comparatively recent phenomenon. Nonetheless, the power of biology-oriented chemical design and synthesis, coupled with significant advances in screening technology, has enabled the discovery of a growing number of small molecules that have improved our understanding of stem cell biology and allowed us to manipulate stem cells in unprecedented ways. This review focuses on recent small molecule studies of (i) the key pathways governing stem cell homeostasis, (ii) the pluripotent stem cell niche, (iii) the directed differentiation of stem cells, (iv) the biology of adult stem cells, and (v) somatic cell reprogramming. In a very short period of time, small molecules have defined a perhaps universally attainable naive ground state of pluripotency, and are facilitating the precise, rapid and efficient differentiation of stem cells into somatic cell populations relevant to the clinic. Finally, following the publication of numerous groundbreaking studies at a pace and consistency unusual for a young field, we are closer than ever to completely eliminating the need for genetic modification in reprogramming.

Exploring stem cell biology with small molecules

2006 ◽  
Vol 2 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Shuibing Chen ◽  
Simon Hilcove ◽  
Sheng Ding
Keyword(s):  
Stem Cell ◽  
Small Molecules ◽  
Cell Biology ◽  
Stem Cell Biology

scholarly journals Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1002
Author(s):  
Fabiola Marino ◽  
Mariangela Scalise ◽  
Eleonora Cianflone ◽  
Luca Salerno ◽  
Donato Cappetta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Stem Cell ◽  
Physical Exercise ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
Heart Function ◽  
Stem Cell Biology ◽  
Myocardial Repair ◽  
Beneficial Effects

Over the years strong evidence has been accumulated showing that aerobic physical exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk. Exercise in healthy subjects fosters physiological remodeling of the adult heart. Concurrently, physical training can significantly slow-down or even reverse the maladaptive pathologic cardiac remodeling in cardiac diseases, improving heart function. The underlying cellular and molecular mechanisms of the beneficial effects of physical exercise on the heart are still a subject of intensive study. Aerobic activity increases cardiovascular nitric oxide (NO) released mainly through nitric oxidase synthase 3 activity, promoting endothelium-dependent vasodilation, reducing vascular resistance, and lowering blood pressure. On the reverse, an imbalance between increasing free radical production and decreased NO generation characterizes pathologic remodeling, which has been termed the “nitroso-redox imbalance”. Besides these classical evidence on the role of NO in cardiac physiology and pathology, accumulating data show that NO regulate different aspects of stem cell biology, including survival, proliferation, migration, differentiation, and secretion of pro-regenerative factors. Concurrently, it has been shown that physical exercise generates physiological remodeling while antagonizes pathologic remodeling also by fostering cardiac regeneration, including new cardiomyocyte formation. This review is therefore focused on the possible link between physical exercise, NO, and stem cell biology in the cardiac regenerative/reparative response to physiological or pathological load. Cellular and molecular mechanisms that generate an exercise-induced cardioprotective phenotype are discussed in regards with myocardial repair and regeneration. Aerobic training can benefit cells implicated in cardiovascular homeostasis and response to damage by NO-mediated pathways that protect stem cells in the hostile environment, enhance their activation and differentiation and, in turn, translate to more efficient myocardial tissue regeneration. Moreover, stem cell preconditioning by and/or local potentiation of NO signaling can be envisioned as promising approaches to improve the post-transplantation stem cell survival and the efficacy of cardiac stem cell therapy.

scholarly journals Challenges for Computational Stem Cell Biology: A Discussion for the Field

2021 ◽  
Vol 16 (1) ◽  
pp. 3-9
Author(s):  
Owen Rackham ◽  
Patrick Cahan ◽  
Nancy Mah ◽  
Samantha Morris ◽  
John F. Ouyang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology

scholarly journals 2002 – GENETIC PREDISPOSITION TO MYELOPROLIFERATIVE NEOPLASMS IMPLICATES HEMATOPOIETIC STEM CELL BIOLOGY

2020 ◽  
Vol 88 ◽  
pp. S27
Author(s):  
Satish Nandakumar ◽  
Erik Bao ◽  
Xiaotian Liao ◽  
Alexander Bick ◽  
Juha Karjalainen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Genetic Predisposition ◽  
Cell Biology ◽  
Myeloproliferative Neoplasms ◽  
Stem Cell Biology ◽  
Hematopoietic Stem

scholarly journals Stem-cell Biology

Nature ◽  
2006 ◽  
Vol 441 (7097) ◽  
pp. 1059-1059 ◽  
Author(s):  
Natalie DeWitt
Keyword(s):  
Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology
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