Transgenic Models of Autophagy

2006 ◽  
pp. 55-67 ◽  
Author(s):  
Noboru Mizushima
Keyword(s):  
Transgenic Models

scholarly journals Zebrafish Models to Study New Pathways in Tauopathies

2021 ◽  
Vol 22 (9) ◽  
pp. 4626
Author(s):  
Clément Barbereau ◽  
Nicolas Cubedo ◽  
Tangui Maurice ◽  
Mireille Rossel
Keyword(s):  
Cognitive Deficits ◽  
Tau Protein ◽  
Common Point ◽  
Transgenic Models ◽  
Synaptic Loss ◽  
Wide Range ◽  
Transgenic Lines ◽  
Functional Consequences ◽  
The Common

Tauopathies represent a vast family of neurodegenerative diseases, the most well-known of which is Alzheimer’s disease. The symptoms observed in patients include cognitive deficits and locomotor problems and can lead ultimately to dementia. The common point found in all these pathologies is the accumulation in neural and/or glial cells of abnormal forms of Tau protein, leading to its aggregation and neurofibrillary tangles. Zebrafish transgenic models have been generated with different overexpression strategies of human Tau protein. These transgenic lines have made it possible to highlight Tau interacting factors or factors which may limit the neurotoxicity induced by mutations and hyperphosphorylation of the Tau protein in neurons. Several studies have tested neuroprotective pharmacological approaches. On few-days-old larvae, modulation of various signaling or degradation pathways reversed the deleterious effects of Tau mutations, mainly hTauP301L and hTauA152T. Live imaging and live tracking techniques as well as behavioral follow-up enable the analysis of the wide range of Tau-related phenotypes from synaptic loss to cognitive functional consequences.

scholarly journals A constitutive pan‐hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs

2010 ◽  
Vol 25 (4) ◽  
pp. 1218-1229 ◽  
Author(s):  
Martin Blume ◽  
Marion Hliscs ◽  
Dayana Rodriguez‐Contreras ◽  
Marco Sanchez ◽  
Scott Landfear ◽  
...  
Keyword(s):  
Life Cycle ◽  
Transgenic Models

scholarly journals Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy

Viruses ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 674 ◽  
Author(s):  
Chiaho Shih ◽  
Chun-Che Liao ◽  
Ya-Shu Chang ◽  
Szu-Yao Wu ◽  
Chih-Shin Chang ◽  
...  
Keyword(s):  
Mouse Models ◽  
Viral Entry ◽  
De Novo ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Clinical Isolates ◽  
Transgenic Models ◽  
User Friendly ◽  
Hybrid Mice

Enterovirus 71 (EV71) is a global health threat. Children infected with EV71 could develop hand-foot-and-mouth disease (HFMD), encephalitis, paralysis, pulmonary edema, and death. At present, no effective treatment for EV71 is available. We reviewed here various mouse models for EV71 pathogenesis and therapy. Earlier studies relied on the use of mouse-adapted EV71 strains. To avoid artificial mutations arising de novo during the serial passages, recent studies used EV71 clinical isolates without adaptation. Several human receptors for EV71 were shown to facilitate viral entry in cell culture. However, in vivo infection with human SCARB2 receptor transgenic mice appeared to be more limited to certain strains and genotypes of EV71. Efficacy of oral infection in these transgenic models is extremely low. Intriguingly, despite the lack of human receptors, immunodeficient neonatal mouse models can still be infected with EV71 clinical isolates via oral or intraperitoneal routes. Crossbreeding between SCARB2 transgenic and stat1 knockout mice generated a more sensitive and user-friendly hybrid mouse model. Infected hybrid mice developed a higher incidence and earlier onset of CNS disease and death. Different pathogenesis profiles were observed in models deficient in various arms of innate or humoral immunity. These models are being actively used for antiviral research.

scholarly journals Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice: The Paradox in Transgenic Models

Diabetes ◽  
2008 ◽  
Vol 57 (7) ◽  
pp. 1861-1869 ◽  
Author(s):  
C.-J. Wang ◽  
F.-C. Chou ◽  
C.-H. Chu ◽  
J.-C. Wu ◽  
S.-H. Lin ◽  
...  
Keyword(s):  
Protective Role ◽  
Diabetic Mice ◽  
Transgenic Models ◽  
Nonobese Diabetic ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Nonobese Diabetic Mice

scholarly journals Application of Exogenously Regulatable Promoter Systems to Transgenic Models for the Study of Aging

1999 ◽  
Vol 54 (1) ◽  
pp. B30-B40 ◽  
Author(s):  
W. W. Morgan ◽  
A. Richardson ◽  
Z. D. Sharp ◽  
C. A. Walter
Keyword(s):  
Transgenic Models
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