Linkers for Solid‐Phase Organic Synthesis (SPOS) and Combinatorial Approaches on Solid Supports

2006 ◽  
pp. 33-110 ◽  
Author(s):  
Willi Bannwarth
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Supports ◽  
Solid Phase Organic Synthesis

scholarly journals Solid-Phase Organic Synthesis and Catalysis: Some Recent Strategies Using Alumina, Silica, and Polyionic Resins

2013 ◽  
Vol 2013 ◽  
pp. 1-20 ◽  
Author(s):  
Basudeb Basu ◽  
Susmita Paul
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Organic Reactions ◽  
Coupling Reactions ◽  
Reaction Parameters ◽  
Solid Supports ◽  
Cross Coupling Reactions ◽  
Solid Phase Organic Synthesis ◽  
Polymeric Solid

Solid-phase organic synthesis (SPOS) and catalysis have gained impetus after the seminal discovery of Merrifield’s solid-phase peptide synthesis and also because of wide applicability in combinatorial and high throughput chemistry. A large number of organic, inorganic, or organic-inorganic hybrid materials have been employed as polymeric solid supports to promote or catalyze various organic reactions. This review article provides a concise account on our approaches involving the use of (i) alumina or silica, either having doped with metal salts or directly, and (ii) polyionic resins to either promote various organic reactions or to immobilize reagents/metal catalysts for subsequent use in hydrogenation and cross-coupling reactions. The reaction parameters, scopes, and limitations, particularly in the context of green chemistry, have been highlighted with pertinent approaches by other groups.

Recent Application of Polystyrene-supported Triphenylphosphine in Solid-Phase Organic Synthesis

2019 ◽  
Vol 23 (6) ◽  
pp. 643-678
Author(s):  
Lalthazuala Rokhum ◽  
Ghanashyam Bez
Keyword(s):  
Organic Synthesis ◽  
Combinatorial Chemistry ◽  
Solid Phase ◽  
Recent Application ◽  
Organic Transformations ◽  
Solid Phase Organic Synthesis ◽  
Wide Range ◽  
Fast Development ◽  
Polymer Supported

Recent years have witnessed a fast development of solid phase synthetic pathways, a variety of solid-supported reagent and its applications in diverse synthetic strategies and pharmaceutical applicability’s. Polymer-supported triphenylphosphine is getting a lot of applications owing to the speed and simplicity in the process. Furthermore, ease of recyclability and reuse of polymer-supported triphenylphosphine added its advantages. This review covers a wide range of useful organic transformations which are accomplished using cross-linked polystyrene-supported triphenylphosphine with the aim of giving renewed interest in the field of organic and medicinal-combinatorial chemistry.

Neutral Reducing Agents Supported on Merrifield Resin Obtained by Solid Phase Organic Synthesis

Tetrahedron ◽  
2021 ◽  
pp. 132195
Author(s):  
Milagros Aguilar-Martínez ◽  
Judas Tadeo Vargas-Durazo ◽  
Adrián Ochoa-Terán ◽  
Hisila Santacruz-Ortega ◽  
Karen Ochoa Lara ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Reducing Agents ◽  
Solid Phase Organic Synthesis ◽  
Merrifield Resin

PhFl acetic acid: A new linker for solid phase organic synthesis

1998 ◽  
Vol 39 (26) ◽  
pp. 4591-4594 ◽  
Author(s):  
Konrad H. Bleicher ◽  
James R. Wareing
Keyword(s):  
Acetic Acid ◽  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis

Solid Phase Organic Synthesis of Piperazinone Containing Enkephalin Mimetics:  A Readily Derivatized, Traceless Scaffold

1999 ◽  
Vol 1 (5) ◽  
pp. 383-387 ◽  
Author(s):  
Kevin Shreder ◽  
Li Zhang ◽  
Jean-Paul Gleeson ◽  
Jens A. Ericsson ◽  
Venkatachalapathi V. Yalamoori ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis

PhFl polystyrene: A new resin for solid phase organic synthesis

1998 ◽  
Vol 39 (26) ◽  
pp. 4587-4590 ◽  
Author(s):  
Konrad H. Bleicher ◽  
James R. Wareing
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis

Perkin 1 Abstracts: Solid Phase Organic Synthesis

1999 ◽  
pp. xi-xiv
Author(s):  
John Christopher ◽  
Catherine McCusker ◽  
Susan Booth ◽  
Jason Tierney
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis
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