Intracellular Lipid Binding Proteins: Evolution, Structure, and Ligand Binding

2004 ◽  
pp. 95-118 ◽  
Author(s):  
Christian Lücke ◽  
Luis H. Gutiérrez-González ◽  
James A. Hamilton
Keyword(s):  
Ligand Binding ◽  
Binding Proteins ◽  
Lipid Binding ◽  
Intracellular Lipid ◽  
Lipid Binding Proteins

The role of dynamics in modulating ligand exchange in intracellular lipid binding proteins

2014 ◽  
Vol 1844 (7) ◽  
pp. 1268-1278 ◽  
Author(s):  
Laura Ragona ◽  
Katiuscia Pagano ◽  
Simona Tomaselli ◽  
Filippo Favretto ◽  
Alberto Ceccon ◽  
...  
Keyword(s):  
Ligand Exchange ◽  
Binding Proteins ◽  
Lipid Binding ◽  
Intracellular Lipid ◽  
Lipid Binding Proteins

scholarly journals INTRACELLULAR LIPID-BINDING PROTEINS AND THEIR GENES

1997 ◽  
Vol 17 (1) ◽  
pp. 277-303 ◽  
Author(s):  
David A. Bernlohr ◽  
Melanie A. Simpson ◽  
Ann Vogel Hertzel ◽  
Leonard J. Banaszak
Keyword(s):  
Binding Proteins ◽  
Lipid Binding ◽  
Intracellular Lipid ◽  
Lipid Binding Proteins

scholarly journals New insights into intracellular lipid binding proteins: The role of buried water

2009 ◽  
Vol 11 (10) ◽  
pp. 2382-2392 ◽  
Author(s):  
Christian Lücke ◽  
Sinian Huang ◽  
Martin Rademacher ◽  
Heinz Rüterjans
Keyword(s):  
Binding Proteins ◽  
Lipid Binding ◽  
Intracellular Lipid ◽  
Lipid Binding Proteins

scholarly journals Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates

Structure ◽  
2016 ◽  
Vol 24 (9) ◽  
pp. 1590-1598 ◽  
Author(s):  
Zahra Assar ◽  
Zahra Nossoni ◽  
Wenjing Wang ◽  
Elizabeth M. Santos ◽  
Kevin Kramer ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Lipid Binding ◽  
Intracellular Lipid ◽  
Folding Intermediates ◽  
Lipid Binding Proteins

Application of divergence entropy to characterize the structure of lipid-binding proteins

2015 ◽  
Vol 11 (3) ◽  
Author(s):  
Roksana Rosicka ◽  
Mateusz Banach ◽  
Irena Roterman-Konieczna
Keyword(s):  
Ligand Binding ◽  
Binding Proteins ◽  
Water Environment ◽  
Lipid Binding ◽  
Ligand Molecule ◽  
Hydrophobic Core ◽  
Binding Cavity ◽  
Static Character ◽  
Lipid Binding Proteins ◽  
Specific Ligand

AbstractThe lipid-binding protein present in the human brain is the object of this analysis. The expression of these proteins is especially important for nervous cell differentiation and their migration in the process of the development of the brain. The “fuzzy oil drop” model applied to the analysis of these proteins may suggest the mechanism of complex generation. It is shown that this type of complex may appear spontaneously in water environment. The presence of ligand does not imply any form of adaptation of the polypeptide chain to the ligand molecule. It can be speculated that ligand binding is of a static character without the necessity for mutual structural fitting. The structures of polypeptide in the apo- and complexed forms do not differ in respect to hydrophobic core formation. Such an interpretation is different than that observed in other ligand-binding proteins where the binding cavity needs to be specially fitted to the specific ligand. It can also be concluded that the lipid-binding process is of low specificity in this case.

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