Structure-Function of CD36 and Evidence for its Role in Facilitating Membrane Fatty Acid Transport

2004 ◽  
pp. 1-29 ◽  
Author(s):  
Chris T. Coburn ◽  
Nada A. Abumrad
Keyword(s):  
Fatty Acid ◽  
Structure Function ◽  
Fatty Acid Transport ◽  
Membrane Fatty Acid ◽  
Acid Transport

scholarly journals New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36

2002 ◽  
Vol 367 (3) ◽  
pp. 561-570 ◽  
Author(s):  
Joep F.F. BRINKMANN ◽  
Nada A. ABUMRAD ◽  
Azeddine IBRAHIMI ◽  
Ger J. vanderVUSSE ◽  
Jan F.C. GLATZ
Keyword(s):  
Plasma Membrane ◽  
Fatty Acid ◽  
Heart Muscle ◽  
Fatty Acid Transport ◽  
Acid Uptake ◽  
Membrane Fatty Acid ◽  
Acid Transport ◽  
Fatty Acid Binding ◽  
Fatty Acid Translocase ◽  
Long Chain

Long-chain fatty acids are an important source of energy for several cell types, in particular for the heart muscle cell. Three different proteins, fatty acid translocase (FAT)/CD36, fatty acid transport protein and plasma membrane fatty acid binding protein, have been identified as possible membrane fatty acid transporters. Much information has been accumulated recently about the fatty acid transporting function of FAT/CD36. Several experimental models to study the influence of altered FAT/CD36 expression on fatty acid homoeostasis have been identified or developed, and underscore the importance of FAT/CD36 for adequate fatty acid transport. These models include the FAT/CD36 null mouse, the spontaneously hypertensive rat and FAT/CD36-deficient humans. The fatty acid transporting role of FAT/CD36 is further demonstrated in mice overexpressing muscle-specific FAT/CD36, and in transgenic mice generated using a genetic-rescue approach. In addition, a wealth of information has been gathered about the mechanisms that regulate FAT/CD36 gene expression and the presence of functional FAT/CD36 on the plasma membrane. Available data also indicate that FAT/CD36 may have an important role in the aetiology of cardiac disease, especially cardiac hypertrophy and diabetic cardiomyopathy. This review discusses our current knowledge of the three candidate fatty acid transporters, the metabolic consequences of alterations in FAT/CD36 levels in different models, and the mechanisms that have been identified for FAT/CD36 regulation.

Intestinal deletion of fatty acid transport protein 4 in mice increases blood chylomicrons

2020 ◽  
Author(s):  
W Chamulitrat ◽  
J Seeßle ◽  
B Javaheri-Haghighi ◽  
S Döring ◽  
X Zhu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein

scholarly journals Effect of a high fat diet on lipid absorption and fatty acid transport in a rat model of short bowel syndrome

2003 ◽  
Vol 19 (5) ◽  
pp. 385-390 ◽  
Author(s):  
Igor Sukhotnik ◽  
A. Semih Gork ◽  
Min Chen ◽  
Robert A. Drongowski ◽  
Arnold G. Coran ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Short Bowel Syndrome ◽  
Rat Model ◽  
High Fat Diet ◽  
Lipid Absorption ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
High Fat ◽  
Short Bowel
Sign in / Sign up

Export Citation Format

Share Document