Applied Molecular Evolution of Enzymes Involved in Synthesis and Repair of DNA

2003 ◽  
pp. 281-307 ◽  
Author(s):  
John F. Davidson ◽  
Jon Anderson ◽  
Haiwei Guo ◽  
Daniel Landis ◽  
Lawrence A. Loeb
Keyword(s):  
Molecular Evolution

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

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