Theoretical Calculations of Metal-Catalyzed Cycloaddition Reactions

2003 ◽  
pp. 301-327
Author(s):  
Karl Anker Jørgensen
Keyword(s):  
Theoretical Calculations ◽  
Cycloaddition Reactions ◽  
Metal Catalyzed

Theoretical and experimental studies of palladium-catalyzed site-selective C(sp3)−H bond functionalization enabled by transient ligands

2017 ◽  
Author(s):  
Haibo Ge ◽  
Lei Pan ◽  
Piaoping Tang ◽  
Ke Yang ◽  
Mian Wang ◽  
...  
Keyword(s):  
Bond Activation ◽  
Theoretical Calculations ◽  
Experimental Studies ◽  
Bond Functionalization ◽  
Aliphatic Ketones ◽  
Site Selectivity ◽  
Mechanistic Investigation ◽  
Palladium Catalyzed ◽  
Metal Catalyzed ◽  
Site Selective

Transition metal-catalyzed selective C–H bond functionalization enabled by transient ligands has become an extremely attractive topic due to its economical and greener characteristics. However, catalytic pathways of this reaction process on unactivated sp<sup>3</sup> carbons of reactants have not been well studied yet. Herein, detailed mechanistic investigation on Pd-catalyzed C(sp<sup>3</sup>)–H bond activation with amino acids as transient ligands has been systematically conducted. The theoretical calculations showed that higher angle distortion of C(sp2)-H bond over C(sp3)-H bond and stronger nucleophilicity of benzylic anion over its aromatic counterpart, leading to higher reactivity of corresponding C(sp<sup>3</sup>)–H bonds; the angle strain of the directing rings of key intermediates determines the site-selectivity of aliphatic ketone substrates; replacement of glycine with β-alanine as the transient ligand can decrease the angle tension of the directing rings. Synthetic experiments have confirmed that β-alanine is indeed a more efficient transient ligand for arylation of β-secondary carbons of linear aliphatic ketones than its glycine counterpart.<br><br>

scholarly journals Transition metal catalyzed [6 + 2] cycloadditions

RSC Advances ◽  
2019 ◽  
Vol 9 (44) ◽  
pp. 25554-25568 ◽  
Author(s):  
Amit Anand ◽  
Prabhpreet Singh ◽  
Vipan Kumar ◽  
Gaurav Bhargava
Keyword(s):  
Transition Metal ◽  
Cycloaddition Reactions ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Synthetic Transformations

The [6 + 2] cycloaddition reactions are one of the important synthetic transformations to construct eight membered carbo-/heterocyclic systems.

ChemInform Abstract: Three-Component Cycloadditions: The First Transition Metal Catalyzed [5 + 2 + 1] Cycloaddition Reactions.

ChemInform ◽  
2010 ◽  
Vol 33 (31) ◽  
pp. no-no
Author(s):  
Paul A. Wender ◽  
Gabriel G. Gamber ◽  
Robert D. Hubbard ◽  
Lei Zhang
Keyword(s):  
Transition Metal ◽  
Cycloaddition Reactions ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed
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