Hepatitis-Free Interval After Clotting Factor Therapy in First Infused Haemophiliacs

1986 ◽  
Vol 56 (03) ◽  
pp. 268-270 ◽  
Author(s):  
M Morfini ◽  
D Rafanelli ◽  
G Longo ◽  
A Messori ◽  
P Rossi Ferrini
Keyword(s):  
Life Table ◽  
Lower Risk ◽  
Clotting Factor ◽  
Rank Test ◽  
Life Table Method ◽  
Table Method ◽  
Log Rank Test ◽  
Free Interval ◽  
Post Infusion ◽  
Clotting Factor Concentrates

SummaryPost-infusion hepatitis is known to occur very frequently in haemophiliacs after treatment with unheated commercial clotting factor concentrates, obtained from large plasma donation pool. On the contrary, single-donor cryoprecipitate is likely to carry a lower risk of transmitting hepatitis.To evaluate this hypothesis, we retrospectively reviewed the medical records of 25 first infused haemophiliacs (from 1981 to 1984) treated with unheated commercial clotting factor concentrates (n = 19) or cryoprecipitate (n = 6).The hepatitis-free interval after the beginning of therapy was expressed as exposure days. The end point of each patient, i.e. the hepatitis occurrence, was defined as an increase of aminotransferases (ALT and AST) and/or the seroconversion of HBV-markers, which were checked every three months.The life-table method and log-rank test showed that cryo-precipitates had a significantly longer hepatitis-free interval (p = 0.0131, log-rank test) and a lower risk of transmitting hepatitis (p = 0.01-0.05, life-table method) than the commercial concentrates. However, the safety of cryoprecipitate therapy was shown to cover only a few exposure days, and so the real advantage of this product depends on the bleeding frequency of the patient concerned.We believe that these methods and our findings may be useful to assess and compare the safety of the new “heat-treated” clotting factor concentrates.

Using Bayesian network models to incorporate uncertainty in the economic analysis of pollution abatement measures under the water framework directive

2005 ◽  
Vol 5 (6) ◽  
pp. 95-104 ◽  
Author(s):  
D.N. Barton ◽  
T. Saloranta ◽  
T.H. Bakken ◽  
A. Lyche Solheim ◽  
J. Moe ◽  
...  
Keyword(s):  
Water Quality ◽  
At Risk ◽  
Economic Valuation ◽  
Pollution Abatement ◽  
Network Models ◽  
Cost Effective ◽  
Bayesian Belief Networks ◽  
Probabilistic Interpretation ◽  
Belief Networks ◽  
Benefit Cost Analysis

The evaluation of water bodies “at risk” of not achieving the Water Framework Directive's (WFD) goal of “good status” begs the question of how big a risk is acceptable before a programme of measures should be implemented. Documentation of expert judgement and statistical uncertainty in pollution budgets and water quality modelling, combined with Monte Carlo simulation and Bayesian belief networks, make it possible to give a probabilistic interpretation of “at risk”. Combined with information on abatement costs, a cost-effective ranking of measures based on expected costs and effect can be undertaken. Combined with economic valuation of water quality, the definition of “disproportionate cost” of abatement measures compared to benefits of achieving “good status” can also be given a probabilistic interpretation. Explicit modelling of uncertainty helps visualize where research and consulting efforts are most critical for reducing uncertainty. Based on data from the Morsa catchment in South-Eastern Norway, this paper discusses the relative merits of using Bayesian belief networks when integrating biophysical modelling results in the benefit-cost analysis of derogations and cost-effectiveness ranking of abatement measures under the WFD.

scholarly journals Comparative demography of the exotic Harmonia axyridis with other aphidophagous coccinellids reared on artificial diet

2014 ◽  
Vol 49 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Julianne Milléo ◽  
Francisco Sales Fernandes ◽  
Wesley Augusto Conde Godoy
Keyword(s):  
Life Table ◽  
Harmonia Axyridis ◽  
Reproductive Rate ◽  
The Other ◽  
Adult Longevity ◽  
Net Reproductive Rate ◽  
Anagasta Kuehniella ◽  
Survival Percentage ◽  
Comparative Demography ◽  
Biological Aspects

The objective of this work was to compare biological aspects and life table parameters of the coccinellids Harmonia axyridis, Cycloneda sanguineaand Hippodamia convergens. Insects were fed eggs of Anagasta kuehniella, and reared at 24.5±1ºC, 70±10% relative humidity, with a 12 hour photophase. Hippodamia convergenstook about 1.6 day to complete development, longer than H. axyridis, and 2.4 day longer than C. sanguinea.At immature stages, H. axyridisexhibited the highest survival percentage (49.2%), in comparison to the other coccinellids. For mean adult longevity, H. convergenswas deficient, in comparison with the other species. Mean period of pre oviposition was the longest in C. sanguinea; the longest oviposition time occurred for H. axyridis; and the post oviposition period was similar between the coccinellids. Considering the reproductive parameters, H. axyridisshowed the best performance in all aspects. For life table, the values of H. convergenswere higher than, although close, to those of H. axyridis. Nevertheless, the high net reproductive rate of H. axyridis showed this species potential to increase population size. The biological characteristics of the exotic H. axyridis favors its invasion and establishment in Brazil, corroborating results noticed in other countries.

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