ISOMERIC SYDNONES: I. THE REACTIONS OF 1- AND 2-BENZOYL-1-METHYLHYDRAZINES AND PHOSGENE

1965 ◽  
Vol 43 (5) ◽  
pp. 1607-1613 ◽  
Author(s):  
C. Ainsworth
Keyword(s):  
Thermal Rearrangement ◽  
Methyl Hydrazine

The oxygen–carbonyl isomeric sydnone (V) has been synthesized from 1-benzoyl-1-methyl-hydrazine hydrochloride (VII) and phosgene. The isosydnone V itself reacts with phosgene to form 2-chloro-5-phenyl-1,3,4-oxadiazole (VI), a new substituted 1,3,4-oxadiazole. Thermal rearrangement of the salt VII takes place at 200° to give 1-benzoyl-2-methylhydrazine, which with phosgene forms the isomer XI. Some mechanistic pathways for these transformations are discussed.

Radiosensitization of Escherichia coli by Methyl Hydrazine and the Effect of Oxygen

Nature ◽  
1967 ◽  
Vol 214 (5085) ◽  
pp. 304-306 ◽  
Author(s):  
H. MOROSON ◽  
D. MARTIN
Keyword(s):  
Escherichia Coli ◽  
Methyl Hydrazine ◽  
Effect Of Oxygen

Synthese neuer 1λ6- und 1λ4,2,4,6-Thiatriazine aus S,S-Diorganosulfodiimiden / Synthesis of Novel 1λ6- and 1λ4,2,4,6-Thiatriazines from S,S-Diorganosulfodiimides

1988 ◽  
Vol 43 (6) ◽  
pp. 763-768 ◽  
Author(s):  
Manfred Haake ◽  
Winfried Jürgler
Keyword(s):  
Ring Closure ◽  
Aliphatic Amines ◽  
Condensation Products ◽  
Methyl Hydrazine

From S,S-diorganosulfodiimides 1a-e with diphenylcyanimidocarbonate (2) via condensation products 3a-e and 6a-d novel heterocycles were obtained. In DMF 3a-c react with aliphatic amines to form 1λ4,2,4,6-thiatriazines 4a-e and 5a, b. With HCl 6a-d can be cyclized to give 1λ6,2,4,6-thiatriazine hydrochlorides 8a-d. These are thermally converted into 1λ4,2,4,6-thiatriazines 4a, f, g. Condensation of 6a with orthoesters and paraformaldehyde affords 1λ6,2,4,6- thiatriazines 9a, b and 10a, whereas 3a, e undergoes ring closure with methyl hydrazine to 1,2,4- triazoles 11a, e.

The effect of L-α-methyl dopa and N-2-hydroxybenzyl-N-methyl hydrazine (NSD 1039) on the blood pressure of renal hypertensive rats

Life Sciences ◽  
1963 ◽  
Vol 2 (3) ◽  
pp. 193-197 ◽  
Author(s):  
Ruth A. Davis ◽  
D.J. Drain ◽  
M. Horlington ◽  
R. Lazare ◽  
Alicja Urbanska
Keyword(s):  
Blood Pressure ◽  
Hypertensive Rats ◽  
Methyl Dopa ◽  
Methyl Hydrazine ◽  
Renal Hypertensive Rats
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