Tele-Substitution Reactions in the Synthesis of a Promising Class of Antimalarials

2020 ◽  
Author(s):  
Marat Korsik ◽  
Edwin Tse ◽  
David Smith ◽  
William Lewis ◽  
Peter J. Rutledge ◽  
...  
Keyword(s):  
Heterocyclic Ring ◽  
Ring System ◽  
Substitution Reactions ◽  
Laboratory Notebook ◽  
Polar Solvents ◽  
X Ray ◽  
X Ray Crystallography ◽  
The Core ◽  
Nmr Data

<p></p><p>We have discovered and studied a <i>tele</i>substitution reaction in a biologically important heterocyclic ring system. Conditions that favour the <i>tele</i>-substitution pathway were identified: the use of increased equivalents of the nucleophile or decreased equivalents of base, or the use of softer nucleophiles, less polar solvents and larger halogens on the electrophile. Using results from X-ray crystallography and isotope labelling experiments a mechanism for this unusual transformation is proposed. We focused on this triazolopyrazine as it is the core structure of the <i>in vivo </i>active anti-plasmodium compounds of Series 4 of the Open Source Malaria consortium.</p> <p> </p> <p>Archive of the electronic laboratory notebook with the description of all conducted experiments and raw NMR data could be accessed via following link <a href="https://ses.library.usyd.edu.au/handle/2123/21890">https://ses.library.usyd.edu.au/handle/2123/21890</a> . For navigation between entries of laboratory notebook please use file "Strings for compounds in the article.pdf" that works as a reference between article codes and notebook codes, also this file contain SMILES for these compounds. </p><br><p></p>

A Miniaturized, No-Moving-Parts Raman Spectrometer

1993 ◽  
Vol 47 (5) ◽  
pp. 539-543 ◽  
Author(s):  
E. Neil Lewis ◽  
Patrick J. Treado ◽  
Ira W. Levin
Keyword(s):  
Solid State ◽  
Laser Excitation ◽  
Photon Counting ◽  
Avalanche Photodiode ◽  
Tunable Filter ◽  
Instrument Design ◽  
Laboratory Notebook ◽  
Raman Spectrometer ◽  
Digitally Controlled ◽  
Moving Parts

A solid-state acousto-optic tunable filter (AOTF) is combined with krypton laser excitation (647 nm), holographic Raman filters, and photon-counting silicon avalanche photodiode (APD) detection to construct a miniaturized Raman spectrometer with no moving parts. The physically compact AOTF and the highly integrated APD provide a rugged, digitally controlled spectrometer of moderate spectral resolution and with a footprint comparable in size to a laboratory notebook. Instrument design details are considered and representative spectra are reported. Potential areas of application for this prototype Raman spectrometer are also discussed.

Pilot Study of an Electronic Laboratory Notebook for Research and Development

2021 ◽  
Author(s):  
Wesley Odom ◽  
Keyword(s):  
Pilot Study ◽  
Research And Development ◽  
Materials Science ◽  
Laboratory Notebook ◽  
Measurement Systems ◽  
Promising Tool ◽  
Multidisciplinary Working ◽  
Proper Training ◽  
Multiple Devices ◽  
Primary Standards

The laboratory notebook is the fundamental record for research and development. The emergence of cloud-based digital tools to replace or augment the laboratory notebook has shown promise for groups that are multidisciplinary, working asynchronously, or in multiple locations. This paper details a recent pilot study conducted by Sandia National Laboratories (SNL) comparing an electronic lab notebook (ELN) with traditional paper lab notebooks (PLN), including members of SNL’s Primary Standards Laboratory (PSL). Partly motivated by a related pilot study conducted at the National Institute of Standards and Technology (NIST), the focus of the present study was on the integrability of an ELN within the unique constraints of a national lab, including security protocols that limit cloud capabilities and limited WIFI. The study used Microsoft OneNote and commercially available mobile computing hardware. The pilot included 18 participants from the PSL, biosciences, and materials science/engineering labs. In addition to OneNote, participants were provided one of two options for a computer to be used as their note taking device (including a stylus). Usability and gap analyses, as well as interviews with pilot participants were conducted by members from Sandia’s human factors group. Findings from this study indicate that ELNs may be particularly useful for teams where sharing of procedures and results is important. Participants believed that use of the ELN increased organization of their work and facilitated reporting much more than paper lab notebooks (PLNs). Other benefits included searchability and capability for access on multiple devices. Many of the identified drawbacks were specific to the unique constraints of working at a national lab, but some constraints are more general (e.g. use of ELNs in wet labs where hazardous materials may be of concern). Overall, it was found with proper training, collaboration on best practices, and technical support, that ELNs appear to be a promising tool for modernizing recording practices in research. Some examples from PSL will be highlighted, including R&D for qualifying measurement systems, calibration processes, and procedures.

scholarly journals OpenLabNotes – An Electronic Laboratory Notebook Extension for OpenLabFramework

2015 ◽  
Vol 12 (3) ◽  
pp. 16-25 ◽  
Author(s):  
Markus List ◽  
Michael Franz ◽  
Qihua Tan ◽  
Jan Mollenhauer ◽  
Jan Baumbach
Keyword(s):  
Information Management ◽  
Data Protection ◽  
Management System ◽  
Laboratory Information Management System ◽  
Digital Signatures ◽  
Information Management System ◽  
Laboratory Notebook ◽  
Scientific Fraud ◽  
Sample Management ◽  
Laboratory Information Management

Summary Electronic laboratory notebooks (ELNs) are more accessible and reliable than their paper based alternatives and thus find widespread adoption. While a large number of commercial products is available, small- to mid-sized laboratories can often not afford the costs or are concerned about the longevity of the providers. Turning towards free alternatives, however, raises questions about data protection, which are not sufficiently addressed by available solutions. To serve as legal documents, ELNs must prevent scientific fraud through technical means such as digital signatures. It would also be advantageous if an ELN was integrated with a laboratory information management system to allow for a comprehensive documentation of experimental work including the location of samples that were used in a particular experiment. Here, we present OpenLabNotes, which adds state-of-the-art ELN capabilities to OpenLabFramework, a powerful and flexible laboratory information management system. In contrast to comparable solutions, it allows to protect the intellectual property of its users by offering data protection with digital signatures. OpenLabNotes effectively closes the gap between research documentation and sample management, thus making Open- LabFramework more attractive for laboratories that seek to increase productivity through electronic data management.

scholarly journals Service Integration to Enhance Research Data Management: RSpace Electronic Laboratory Notebook Case Study

2015 ◽  
Vol 10 (1) ◽  
pp. 163-172 ◽  
Author(s):  
Stuart Macdonald ◽  
Rory Macneil
Keyword(s):  
Data Management ◽  
Research Output ◽  
Service Integration ◽  
Research Data ◽  
Responsible Conduct Of Research ◽  
It Services ◽  
Laboratory Notebook ◽  
Research Data Management ◽  
Research Administrators ◽  
Working Together

Research Data Management (RDM) provides a framework that supports researchers and their data throughout the course of their research and is increasingly regarded as one of the essential areas of responsible conduct of research. New tools and infrastructures make possible the generation of large volumes of digital research data in a myriad of formats. This facilitates new ways to analyse, share and reuse these outputs, with libraries, IT services and other service units within academic institutions working together with the research community to develop RDM infrastructures to curate and preserve this type of research output and make them re-usable for future generations. Working on the principle that a rationalised and continuous flow of data between systems and across institutional boundaries is one of the core goals of information management, this paper will highlight service integration via Electronic Laboratory Notebooks (ELN), which streamline research data workflows, result in efficiency gains for researchers, research administrators and other stakeholders, and ultimately enhance the RDM process.

RS/1: an electronic laboratory notebook

BioScience ◽  
1985 ◽  
Vol 35 (9) ◽  
pp. 588-590
Author(s):  
W. A. Gilbert
Keyword(s):  
Laboratory Notebook ◽  
Electronic Laboratory Notebook

LabTablet: Semantic Metadata Collection on a Multi-domain Laboratory Notebook

2014 ◽  
pp. 193-205 ◽  
Author(s):  
Ricardo Carvalho Amorim ◽  
João Aguiar Castro ◽  
João Rocha da Silva ◽  
Cristina Ribeiro
Keyword(s):  
Laboratory Notebook ◽  
Semantic Metadata

Good Laboratory Notebook Practices

2003 ◽  
Vol 37 (2) ◽  
pp. 215-219 ◽  
Author(s):  
King C. Lee
Keyword(s):  
Laboratory Notebook ◽  
Good Laboratory

Successful implementation of inquiry-based physiology laboratories in undergraduate major and nonmajor courses

2008 ◽  
Vol 32 (4) ◽  
pp. 286-296 ◽  
Author(s):  
G. Casotti ◽  
L. Rieser-Danner ◽  
M. T. Knabb
Keyword(s):  
Thinking Skills ◽  
Human Anatomy ◽  
Successful Implementation ◽  
Laboratory Notebook ◽  
Undergraduate Major ◽  
Inquiry Based Learning ◽  
Anatomy And Physiology ◽  
Analytical Thinking ◽  
Human Anatomy And Physiology ◽  
Oral Presentations

Recent evidence has demonstrated that inquiry-based physiology laboratories improve students' critical- and analytical-thinking skills. We implemented inquiry-based learning into three physiology courses: Comparative Vertebrate Physiology (majors), Human Physiology (majors), and Human Anatomy and Physiology (nonmajors). The aims of our curricular modifications were to improve the teaching of physiological concepts, teach students the scientific approach, and promote creative and critical thinking. We assessed our modifications using formative (laboratory exams, oral presentations, and laboratory reports) and summative evaluations (surveys, laboratory notebook, and an end of semester project). Students appreciated the freedom offered by the new curriculum and the opportunity to engage in the inquiry process. Results from both forms of evaluation showed a marked improvement due to the curricular revisions. Our analyses indicate an increased confidence in students' ability to formulate questions and hypotheses, design experiments, collect and analyze data, and make conclusions. Thus, we have successfully incorporated inquiry-based laboratories in both major and nonmajor courses.

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