Promoter Optimization and Artificial Promoters for Transcriptional Targeting in Gene Therapy

2003 ◽  
pp. 481-503
Author(s):  
Dirk M. Nettelbeck ◽  
David T. Curiel ◽  
Rolf Müller
Keyword(s):  
Gene Therapy ◽  
Transcriptional Targeting ◽  
Promoter Optimization

scholarly journals Comparative evaluation of survivin, midkine, and CXCR4 promoters for transcriptional targeting of glioma gene therapy

2007 ◽  
Vol 6 (5) ◽  
pp. 679-685 ◽  
Author(s):  
Ilya V. Ulasov ◽  
Angel A. Rivera ◽  
Adam M. Sonabend ◽  
Adam M. Sonabend ◽  
Ming Wang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Comparative Evaluation ◽  
Transcriptional Targeting

Transcriptional Targeting for Ovarian Cancer Gene Therapy

2001 ◽  
Vol 82 (2) ◽  
pp. 229-237 ◽  
Author(s):  
E. Casado ◽  
D.M. Nettelbeck ◽  
J. Gomez-Navarro ◽  
A. Hemminki ◽  
M. Gonzalez Baron ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Transcriptional Targeting

scholarly journals Transcriptional Targeting in Cancer Gene Therapy

2003 ◽  
Vol 2003 (2) ◽  
pp. 110-137 ◽  
Author(s):  
Tracy Robson ◽  
David G. Hirst
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
Cancer Treatments ◽  
Transcriptional Targeting ◽  
Exogenous Agents ◽  
Therapeutic Research ◽  
Systemic Gene Delivery ◽  
Near Future

Cancer gene therapy has been one of the most exciting areas of therapeutic research in the past decade. In this review, we discuss strategies to restrict transcription of transgenes to tumour cells. A range of promoters which are tissue-specific, tumour-specific, or inducible by exogenous agents are presented. Transcriptional targeting should prevent normal tissue toxicities associated with other cancer treatments, such as radiation and chemotherapy. In addition, the specificity of these strategies should provide improved targeting of metastatic tumours following systemic gene delivery. Rapid progress in the ability to specifically control transgenes will allow systemic gene delivery for cancer therapy to become a real possibility in the near future.

scholarly journals Telomerase Transcriptional Targeting of Inducible Bax/TRAIL Gene Therapy Improves Gemcitabine Treatment of Pancreatic Cancer

2008 ◽  
Vol 16 (2) ◽  
pp. 252-260 ◽  
Author(s):  
Séverine Wack ◽  
Soukaina Rejiba ◽  
Céline Parmentier ◽  
Marc Aprahamian ◽  
Amor Hajri
Keyword(s):  
Pancreatic Cancer ◽  
Gene Therapy ◽  
Transcriptional Targeting ◽  
Gemcitabine Treatment

scholarly journals Toward gene therapy of endometriosis: transductional and transcriptional targeting of adenoviral vectors to endometriosis cells

2008 ◽  
Vol 199 (2) ◽  
pp. 117.e1-117.e6 ◽  
Author(s):  
Essam-Eldin R. Othman ◽  
Zeng B. Zhu ◽  
David T. Curiel ◽  
Nilufar Khatoon ◽  
Hosam T. Salem ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Adenoviral Vectors ◽  
Transcriptional Targeting

Control of gene therapy by MDR1 and EGR1 promoter sequences in transcriptional targeting by chemotherapy (Review)

2004 ◽  
Author(s):  
Carlos Lopez ◽  
James Park ◽  
Helena Mauceri ◽  
Michael Beckett ◽  
Ralph Weichselbaum ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Transcriptional Targeting ◽  
Promoter Sequences
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