Therapeutic Implications of Circadian Rhythms in Cancer Patients

2008 ◽  
pp. 119-142 ◽  
Author(s):  
Francis Lévi
Keyword(s):  
Circadian Rhythms ◽  
Cancer Patients ◽  
Therapeutic Implications

Prognostic impact and therapeutic implications of sentinel lymph node micro-metastases in early-stage breast cancer patients

2011 ◽  
Vol 103 (6) ◽  
pp. 531-533 ◽  
Author(s):  
Carsten T. Viehl ◽  
Igor Langer ◽  
Ulrich Guller ◽  
Rosanna Zanetti-Dällenbach ◽  
Holger Moch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cancer Patients ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Prognostic Impact ◽  
Breast Cancer Patients ◽  
Therapeutic Implications

scholarly journals Skin surface temperature rhythms as potential circadian biomarkers for personalized chronotherapeutics in cancer patients

2010 ◽  
Vol 1 (1) ◽  
pp. 48-60 ◽  
Author(s):  
Christopher G. Scully ◽  
Abdoulaye Karaboué ◽  
Wei-Min Liu ◽  
Joseph Meyer ◽  
Pasquale F. Innominato ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Skin Temperature ◽  
Cancer Patients ◽  
Infrared Imaging ◽  
Core Body Temperature ◽  
Dynamic Assessment ◽  
Invasive Approach ◽  
Circadian Timing ◽  
Circadian Phase ◽  
Temperature Rhythms

Chronotherapeutics involve the administration of treatments according to circadian rhythms. Circadian timing of anti-cancer medications has been shown to improve treatment tolerability up to fivefold and double efficacy in experimental and clinical studies. However, the physiological and the molecular components of the circadian timing system (CTS), as well as gender, critically affect the success of a standardized chronotherapeutic schedule. In addition, a wrongly timed therapy or an excessive drug dose disrupts the CTS. Therefore, a non-invasive approach to accurately detect and monitor circadian rhythms is needed for a dynamic assessment of the CTS in order to personalize chronomodulated drug delivery schedule in cancer patients. Since core body temperature is a robust circadian biomarker, we recorded temperature at multiple locations on the skin of the upper chest and back of controls and cancer patients continuously. Variability in the circadian phase existed among patch locations in individual subjects over the course of 2–6 days, demonstrating the need to monitor multiple skin temperature locations to determine the precise circadian phase. Additionally, we observed that locations identified by infrared imaging as relatively cool had the largest 24 h temperature variations. Disruptions in skin temperature rhythms during treatment were found, pointing to the need to continually assess circadian timing and personalize chronotherapeutic schedules.

scholarly journals Correlation of Blood and Salivary Levels of Zinc, Iron and Copper in Head and Neck Cancer Patients: An Investigational Study

2017 ◽  
Vol 5 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Thomas George ◽  
Jogappanavar Basappa Honnamurthy ◽  
Arnadi Ramachandrayya Shivashankara ◽  
Sucharitha Suresh ◽  
Manjeshwar Shrinath Baliga
Keyword(s):  
Head And Neck ◽  
Cancer Patients ◽  
Control Group ◽  
College Hospital ◽  
Therapeutic Implications ◽  
Spectrophotometric Methods ◽  
Iron Copper ◽  
Copper And Zinc ◽  
Whole Saliva ◽  
Iron And Zinc

Background: Metals like copper, iron and zinc have been suggested to modulate free radical generation and carcinogenesis. In lieu of these observations, estimation of these metals is vital and most studies have been with the blood. Objectives: In the present study we estimated the levels of these metals in both serum and saliva of the head and neck (H&N) cancer patients and compared it with healthy age-matched control group. A correlation between the levels of these metals in the serum and saliva of respective H&N cancer patient was also assessed. Materials and Methods: The subjects of this study were the clinically confirmed cases of H&N cancers visiting the Oncology Department of Medical College Hospital for treatment. Age and sex-matched healthy individuals were included as control group. The levels of iron, copper and zinc were estimated in whole saliva and serum by standard spectrophotometric methods. Results: When compared to the controls, the levels of iron and copper were higher in serum and saliva was high in the H&N cancer patients and statically significant (P=.0002 to P=.0001). On the contrary, there was a decrease in the levels of zinc but was not significant. There was significant correlation between serum and saliva with respect to the levels of iron, copper and zinc in H&N cancer patients and was statically significant (P=.0001). Conclusions: The findings of this study indicated the role of metals in etiopathogenesis of H&N cancer. An assessment of the levels of metals in cancer patients might have prognostic and therapeutic implications. This study observed a significant positive correlation between serum and saliva which will go a long way in establishing saliva as a diagnostic tool complimentary to blood.

Cancer pain syndromes: overview

2015 ◽  
Author(s):  
Nathan I. Cherny
Keyword(s):  
Cancer Therapy ◽  
Cancer Pain ◽  
Cancer Patients ◽  
Underlying Disease ◽  
Therapeutic Interventions ◽  
Therapeutic Implications ◽  
Pain Syndromes ◽  
Chronic Cancer Pain ◽  
Pain Characteristics ◽  
Tumour Infiltration

Cancer pain syndromes are defined by the association of particular pain characteristics and physical signs with specific consequences of the underlying disease or its treatment. The recognition of cancer pain syndromes and the ability to distinguish between them is a critical skill for palliative care clinicians since syndromes are associated with distinct aetiologies and pathophysiologies, and they often have important prognostic and therapeutic implications. Pain syndromes associated with cancer can be either acute or chronic. Whereas acute pains experienced by cancer patients are usually related to diagnostic and therapeutic interventions, chronic pains are most commonly caused by direct tumour infiltration. Adverse consequences of cancer therapy, including surgery, chemotherapy, and radiation therapy, account for 15-25% of chronic cancer pain problems, and a small proportion of the chronic pains experienced by cancer patients are caused by pathology unrelated to either the cancer or the cancer therapy.

Relationships of Circadian Rhythms and Physical Activity With Objective Sleep Parameters in Lung Cancer Patients

2015 ◽  
Vol 38 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Hui-Mei Chen ◽  
Yu-Chung Wu ◽  
Chun-Ming Tsai ◽  
Jann-Inn Tzeng ◽  
Chia-Chin Lin
Keyword(s):  
Physical Activity ◽  
Lung Cancer ◽  
Circadian Rhythms ◽  
Cancer Patients ◽  
Lung Cancer Patients ◽  
Sleep Parameters
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