Embryonic Development and the Principles of Tissue Engineering

2008 ◽  
pp. 17-33 ◽  
Author(s):  
Arnold I. Caplan
Keyword(s):  
Tissue Engineering ◽  
Embryonic Development

scholarly journals Native cardiac environment and its impact on engineering cardiac tissue

2019 ◽  
Vol 7 (9) ◽  
pp. 3566-3580 ◽  
Author(s):  
Verena Schwach ◽  
Robert Passier
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Embryonic Development ◽  
Human Heart ◽  
Cardiac Tissue ◽  
Cardiac Tissue Engineering ◽  
Adult Human ◽  
Natural And Synthetic

In this review, we describe the progressive build-up of the cardiac extracellular matrix (ECM) during embryonic development, the ECM of the adult human heart and the application of natural and synthetic biomaterials for cardiac tissue engineering using hPSC-CMs.

scholarly journals Informing tendon tissue engineering with embryonic development

2014 ◽  
Vol 47 (9) ◽  
pp. 1964-1968 ◽  
Author(s):  
Zachary A. Glass ◽  
Nathan R. Schiele ◽  
Catherine K. Kuo
Keyword(s):  
Tissue Engineering ◽  
Embryonic Development ◽  
Tendon Tissue ◽  
Tendon Tissue Engineering

Live Confocal Analysis of Fertilization and Early Development

2001 ◽  
Vol 7 (S2) ◽  
pp. 1012-1013
Author(s):  
Uyen Tram ◽  
William Sullivan
Keyword(s):  
Drosophila Melanogaster ◽  
Embryonic Development ◽  
Real Time ◽  
Early Development ◽  
Fluorescent Probes ◽  
Primary Defect ◽  
Fluorescent Analysis ◽  
Dynamic Event ◽  
Enormous Amount ◽  
Fluorescent Studies

Embryonic development is a dynamic event and is best studied in live animals in real time. Much of our knowledge of the early events of embryogenesis, however, comes from immunofluourescent analysis of fixed embryos. While these studies provide an enormous amount of information about the organization of different structures during development, they can give only a static glimpse of a very dynamic event. More recently real-time fluorescent studies of living embryos have become much more routine and have given new insights to how different structures and organelles (chromosomes, centrosomes, cytoskeleton, etc.) are coordinately regulated. This is in large part due to the development of commercially available fluorescent probes, GFP technology, and newly developed sensitive fluorescent microscopes. For example, live confocal fluorescent analysis proved essential in determining the primary defect in mutations that disrupt early nuclear divisions in Drosophila melanogaster. For organisms in which GPF transgenics is not available, fluorescent probes that label DNA, microtubules, and actin are available for microinjection.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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