Regulation of Ca2+ Entry Pathways by Both Limbs of the Phosphoinositide Pathway

2008 ◽  
pp. 91-107 ◽  
Author(s):  
Colin W. Taylor
Keyword(s):  
Phosphoinositide Pathway

scholarly journals Angiotensin-induced desensitization of the phosphoinositide pathway in cardiac cells occurs at the level of the receptor.

1991 ◽  
Vol 69 (3) ◽  
pp. 800-809 ◽  
Author(s):  
M M Abdellatif ◽  
C F Neubauer ◽  
W J Lederer ◽  
T B Rogers
Keyword(s):  
Cardiac Cells ◽  
Phosphoinositide Pathway

91 DERANGEMENT OF THE PHOSPHOINOSITIDE PATHWAY BY TNFα IN RAT CARDIOMYOCYTES

Shock ◽  
1995 ◽  
Vol 3 (5) ◽  
pp. 28
Author(s):  
C. Reithmann ◽  
T. Bulgan ◽  
K. Werdan
Keyword(s):  
Rat Cardiomyocytes ◽  
Phosphoinositide Pathway

Low-dose endothelin-1 potentiates volume-induced secretion of atrial natriuretic factor

1992 ◽  
Vol 263 (3) ◽  
pp. H939-H944 ◽  
Author(s):  
J. Donckier ◽  
C. Hanet ◽  
L. Galanti ◽  
L. Stoleru ◽  
H. Van Mechelen ◽  
...  
Keyword(s):  
Heart Rate ◽  
Atrial Natriuretic Factor ◽  
Left Atrial ◽  
Low Dose ◽  
Endothelin 1 ◽  
Natriuretic Factor ◽  
Free Intracellular Calcium ◽  
Phosphoinositide Pathway ◽  
Atrial Natriuretic

To evaluate the role of calcium in volume-induced secretion of atrial natriuretic factor (ANF), effects of verapamil and endothelin-1 (ET-1), both known to influence free intracellular calcium, were studied during saline infusion in seven conscious instrumented dogs. Fifteen minutes after intravenous injection of placebo or verapamil (0.25 mg/kg) or during continuous ET-1 infusion (at 5 ng.kg-1.min-1), saline (10% body wt) was infused during 40 min. Saline produced a rise (P less than 0.001) of plasma ANF from 28.1 +/- 6.3 to 50.4 +/- 12.9 pM after placebo, from 30.2 +/- 6.1 to 51.1 +/- 8.5 pM after verapamil, and from 31.2 +/- 6.1 to 81.0 +/- 12.9 pM with ET-1. This increase was comparable after placebo and verapamil, but was 80% greater with ET-1 (P less than 0.02). Plasma ET-1, unchanged after placebo, rose (P less than 0.001) from 1.7 +/- 0.5 to 38.3 +/- 9.2 pM with ET-1. In the three experiments, heart rate and left atrial pressure (LAP) increased (P less than 0.001) similarly. The linear relation between ANF and LAP was steeper with ET-1 than with saline or verapamil (both P less than 0.05), indicating that the enhanced ANF secretion with ET-1 was occurring at all levels of LAP. Thus volume-induced secretion of ANF is not suppressed by verapamil, but is directly enhanced by low-dose ET-1, known to activate the phosphoinositide pathway.

Dibutyltin Dilaurate Induced Thymic Atrophy and Modulation of Phosphoinositide Pathway of Cell Signalling in Thymocytes of Rats

1994 ◽  
Vol 16 (4) ◽  
pp. 645-677 ◽  
Author(s):  
Appian Subramoniam ◽  
Shashi Khandelwal ◽  
Premendra D. Dwivedi ◽  
Santosh Khanna ◽  
Ravi Shanker
Keyword(s):  
Cell Signalling ◽  
Dibutyltin Dilaurate ◽  
Thymic Atrophy ◽  
Phosphoinositide Pathway
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