Role of the Sarcoplasmic Reticulum in Uterine Smooth Muscle

2008 ◽  
pp. 6-25 ◽  
Author(s):  
Susan Wray ◽  
Sajeera Kupittayanant ◽  
Tony Shmigol
Keyword(s):  
Smooth Muscle ◽  
Sarcoplasmic Reticulum ◽  
Uterine Smooth Muscle

scholarly journals Role of Calcium Binding by Sarcoplasmic Reticulum in the Contraction and Relaxation of Uterine Smooth Muscle

1969 ◽  
Vol 53 (4) ◽  
pp. 414-426 ◽  
Author(s):  
Mary E. Carsten
Keyword(s):  
Smooth Muscle ◽  
Sarcoplasmic Reticulum ◽  
Atpase Activity ◽  
Calcium Binding ◽  
Sucrose Density Gradient ◽  
Differential Centrifugation ◽  
Uterine Smooth Muscle ◽  
Fraction I ◽  
Contraction And Relaxation

The binding of calcium by isolated sarcoplasmic reticulum from cow uterus was studied. Sarcoplasmic reticulum was prepared by differential centrifugation. Three fractions were obtained: I, sedimented between 2,500–15,000 x g; II at 40,000 x g; and III, at 150,000 x g. Fraction II was further purified on a sucrose density gradient. All three fractions contained considerable amounts of intrinsic calcium, mostly in fraction I. Calcium binding in the presence of ATP1 and Mg also was greatest in fraction I, followed by fraction II, with less in fraction III. Without ATP no calcium was taken up. 5 and 10 mM sodium azide partially inhibited calcium binding in fraction I, but not in fraction II, suggesting the presence of some mitochondria or mitochondrial fragments in fraction I. Calcium binding in fraction II was completely inhibited by 3 mM salyrgan; this fraction thus appears to be sarcoplasmic reticulum. ATPase activity was found in all three fractions, highest in fraction II. It is computed that calcium binding in fractions I and II, on the basis of a 50% yield of protein, is sufficient to elicit contraction by supplying calcium to the contractile proteins of the smooth muscle cell and to regulate relaxation and contraction.

Malignant uterine smooth muscle tumors: Role of etoposide, cisplatin, and doxorubicin (EPA) chemotherapy

1996 ◽  
Vol 63 (3) ◽  
pp. 145-147 ◽  
Author(s):  
E. Resnik ◽  
S. K. Chambers ◽  
M. L. Carcangiu ◽  
E. I. Kohorn ◽  
P. E. Schwartz ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Uterine Smooth Muscle ◽  
Smooth Muscle Tumors

The role of hypoxia related angiogenesis in uterine smooth muscle tumors

2014 ◽  
Vol 90 (2) ◽  
pp. 102-110 ◽  
Author(s):  
Et Uluer ◽  
S Inan ◽  
K Ozbilgin ◽  
F Karaca ◽  
N Dicle ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Uterine Smooth Muscle ◽  
Smooth Muscle Tumors

Role of Sarcoplasmic Reticulum in the Contractile Function of Vascular Smooth Muscle as Studied by 2,5-Di-(Tert-Butyl)-1,4-Benzohydroquinone

Neurosignals ◽  
1992 ◽  
Vol 1 (4) ◽  
pp. 182-193 ◽  
Author(s):  
Hiroyuki Shimamoto ◽  
Ingrid L.A. Majarais ◽  
Yoriko Shimamoto ◽  
Chiu-Yin Kwan ◽  
Edwin E. Daniel
Keyword(s):  
Smooth Muscle ◽  
Sarcoplasmic Reticulum ◽  
Vascular Smooth Muscle ◽  
Contractile Function ◽  
Tert Butyl

scholarly journals A Theory of the Mechanism of Cerebral Vasospasm and Its Reversal, the Role of Calcium and Cyclic AMP

1976 ◽  
Vol 3 (4) ◽  
pp. 223-226 ◽  
Author(s):  
Eric W. Peterson ◽  
Richard Leblanc
Keyword(s):  
Smooth Muscle ◽  
Subarachnoid Hemorrhage ◽  
Sarcoplasmic Reticulum ◽  
Cyclic Amp ◽  
Smooth Muscle Cell ◽  
Calcium Ion ◽  
Basic Mechanism ◽  
Free Intracellular Calcium ◽  
Intracellular Calcium Ion

SUMMARY:It is proposed that the basic mechanism of vasospasm which sometimes follows subarachnoid hemorrhage is dependent on increased free intracellular calcium ion produced by spasmogens from closely applied extravasated blood. Relaxation of this spasm occurs when the intracellular cyclic AMP levels are raised, resulting in sequestration of calcium ion by the vascular smooth muscle cell sarcoplasmic reticulum.

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