Melt Behaviour of Block Copolymers

Self-Assembly of Hydrogels From Elastin-Mimetic Block Copolymers

MRS Proceedings ◽

10.1557/proc-724-n8.1 ◽

2002 ◽

Vol 724 ◽

Author(s):

Elizabeth R. Wright ◽

R. Andrew McMillan ◽

Alan Cooper ◽

Robert P. Apkarian ◽

Vincent P. Conticello

Keyword(s):

Block Copolymers ◽

Self Assembly ◽

Triblock Copolymers ◽

Variable Temperature ◽

Inverse Temperature ◽

Temperature Transition ◽

Scanning Calorimetry ◽

Design Synthesis ◽

Inverse Temperature Transition ◽

Functional Biomaterials

AbstractTriblock copolymers have traditionally been synthesized with conventional organic components. However, triblock copolymers could be synthesized by the incorporation of two incompatible protein-based polymers. The polypeptides would differ in their hydrophobicity and confer unique physiochemical properties to the resultant materials. One protein-based polymer, based on a sequence of native elastin, that has been utilized in the synthesis of biomaterials is poly (Valine-Proline-Glycine-ValineGlycine) or poly(VPGVG) [1]. This polypeptide has been shown to have an inverse temperature transition that can be adjusted by non-conservative amino acid substitutions in the fourth position [2]. By combining polypeptide blocks with different inverse temperature transition values due to hydrophobicity differences, we expect to produce amphiphilic polypeptides capable of self-assembly into hydrogels. Our research examines the design, synthesis and characterization of elastin-mimetic block copolymers as functional biomaterials. The methods that are used for the characterization include variable temperature 1D and 2D High-Resolution-NMR, cryo-High Resolutions Scanning Electron Microscopy and Differential Scanning Calorimetry.

Download Full-text

Use of Nonionic Block Copolymers in Vaccines and Therapeutics

Critical Reviews in Therapeutic Drug Carrier Systems ◽

10.1615/critrevtherdrugcarriersyst.v15.i2.10 ◽

1998 ◽

Vol 15 (2) ◽

pp. 89-142 ◽

Cited By ~ 30

Author(s):

Mark J. Newman ◽

Jeffrey K. Actor ◽

Mannersamy Balusubramanian ◽

Chinnaswamy Jagannath

Keyword(s):

Block Copolymers

Download Full-text

Mechanical and Structural Consequences of Associative Dynamic Cross-Linking in Acrylic Diblock Copolymers

10.26434/chemrxiv.10000232.v1 ◽

2019 ◽

Author(s):

Jacob Ishibashi ◽

Yan Fang ◽

Julia Kalow

Keyword(s):

Block Copolymers ◽

Rheological Properties ◽

Diblock Copolymers ◽

Cross Linking ◽

Statistical Copolymer

<p>Block copolymers are used to construct covalent adaptable networks that employ associative exchange chemistry (vitrimers). The resulting vitrimers display markedly different nanostructural, thermal and rheological properties relative to those of their statistical copolymer-derived counterparts. This study demonstrates that prepolymer sequence is a versatile strategy to modify the properties of vitrimers.</p>

Download Full-text