The Epithelium in Inflammatory Bowel Disease: Potential Role of Endocytosis of Junctional Proteins in Barrier Disruption

2008 ◽  
pp. 115-132 ◽  
Author(s):  
Andrei I. Ivanov ◽  
Asma Nusrat ◽  
Charles A. Parkos
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Potential Role ◽  
Barrier Disruption ◽  
Junctional Proteins ◽  
Inflammatory Bowel

scholarly journals What Are the Legal Mechanisms for Seeking Solutions to Disparities in the Delivery of Care in the NHS and Where Does Liability Lie?

2021 ◽  
Vol 32 (1) ◽  
pp. 51-86
Author(s):  
Affifa Farrukh
Keyword(s):  
Inflammatory Bowel Disease ◽  
National Health Service ◽  
Health Service ◽  
Bowel Disease ◽  
Potential Role ◽  
Delivery Of Care ◽  
The United Kingdom ◽  
Fit For Purpose ◽  
Inflammatory Bowel

This review deals with the potential role of Commissions and Inquiries into delivering a just service to patients from ethnic minorities. It takes as an example the experience of people with inflammatory bowel disease and the National Health Service in the United Kingdom. Although there are many legal safeguards, the avenues open to groups of patients who experience discrimination, are limited and generally ineffective. Government inspired responses such as Commissions and Inquiries are inadequate and not fit for purpose.

scholarly journals PPARγin Inflammatory Bowel Disease

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Vito Annese ◽  
Francesca Rogai ◽  
Alessia Settesoldi ◽  
Siro Bagnoli
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Potential Role ◽  
Intestinal Inflammation ◽  
Experimental Colitis ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Beneficial Effects ◽  
Inflammatory Bowel

Peroxisome proliferator-activated receptor gamma (PPARγ) is member of a family of nuclear receptors that interacts with nuclear proteins acting as coactivators and corepressors. The colon is a major tissue which expresses PPARγin epithelial cells and, to a lesser degree, in macrophages and lymphocytes and plays a role in the regulation of intestinal inflammation. Indeed, both natural and synthetic PPARγligands have beneficial effects in different models of experimental colitis, with possible implication in the therapy of inflammatory bowel disease (IBD). This paper will specifically focus on potential role of PPARγin the predisposition and physiopathology of IBD and will analyze its possible role in medical therapy.

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