Bioinformatics Approaches to Integrate Cancer Models and Human Cancer Research

2006 ◽  
pp. 155-168
Author(s):  
Cheryl L. Marks ◽  
Sue Dubman
Keyword(s):  
Cancer Research ◽  
Human Cancer ◽  
Cancer Models

Introduction to bioprinting of in vitro cancer models

2021 ◽  
Author(s):  
Hee-Gyeong Yi
Keyword(s):  
Cancer Research ◽  
Cancer Progression ◽  
Human Cancer ◽  
Future Perspective ◽  
Cancer Tissue ◽  
Cancer Resistance ◽  
Cancer Pathology ◽  
Cancer Models ◽  
Tissue Models

Abstract Cancer models are essential in cancer research and for new drug development pipelines. However, conventional cancer tissue models have failed to capture the human cancer physiology, thus hindering drug discovery. The major challenge is the establishment of physiologically relevant cancer models that reflect the complexity of the tumor microenvironment (TME). The TME is a highly complex milieu composed of diverse factors that are associated with cancer progression and metastasis, as well as with the development of cancer resistance to therapeutics. To emulate the TME, 3D bioprinting has emerged as a way to create engineered cancer tissue models. Bioprinted cancer tissue models have the potential to recapitulate cancer pathology and increased drug resistance in an organ-mimicking 3D environment. This review overviews the bioprinting technologies used for the engineering of cancer tissue models and provides a future perspective on bioprinting to further advance cancer research.

scholarly journals New insights on CRISPR/Cas9-based therapy for breast Cancer

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Hussein Sabit ◽  
Shaimaa Abdel-Ghany ◽  
Huseyin Tombuloglu ◽  
Emre Cevik ◽  
Amany Alqosaibi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Research ◽  
Animal Models ◽  
Human Cancer ◽  
Step Process ◽  
Cancer Initiation ◽  
Malignant State ◽  
Treat Breast Cancer

AbstractCRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result in the hallmark of the malignant state. The goal of cancer research is to identify these mutations and correlate them with the underlying tumorigenic process. Using CRISPR/Cas9 tool, specific mutations responsible for cancer initiation and/or progression could be corrected at least in animal models as a first step towards translational applications. In the present article, we review various novel strategies that employed CRISPR/Cas9 to treat breast cancer in both in vitro and in vivo systems.

scholarly journals Conventionally used reference genes are not outstanding for normalization of gene expression in human cancer research

2019 ◽  
Vol 20 (S10) ◽  
Author(s):  
Jihoon Jo ◽  
Sunkyung Choi ◽  
Jooseong Oh ◽  
Sung-Gwon Lee ◽  
Song Yi Choi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Research ◽  
Reference Genes ◽  
Human Cancer

Abstract A194: OTX008, a small molecule that inhibits galectin-1, potentiates the in vitro effects of cytotoxic and targeted agents in several human cancer models.

2013 ◽  
Author(s):  
Lucile Astorgues-xerri ◽  
Maria Eugenia Riveiro ◽  
Kay Noel ◽  
Esteban Cvitkovic ◽  
Mohamed Bekradda ◽  
...  
Keyword(s):  
Small Molecule ◽  
Human Cancer ◽  
Targeted Agents ◽  
Cancer Models ◽  
In Vitro Effects

scholarly journals Translating Human Cancer Sequences Into Personalized Porcine Cancer Models

2019 ◽  
Vol 9 ◽  
Author(s):  
Chunlong Xu ◽  
Sen Wu ◽  
Lawrence B. Schook ◽  
Kyle M. Schachtschneider
Keyword(s):  
Human Cancer ◽  
Cancer Models

scholarly journals TUMOR INOCULATION INTO ORGANS AND THE ANALOGY BETWEEN HUMAN CANCER AND THE TUMORS OF WHITE MICE AND WHITE RATS

1912 ◽  
Vol 16 (2) ◽  
pp. 155-164 ◽  
Author(s):  
Isaac Levin
Keyword(s):  
Cancer Research ◽  
Human Cancer ◽  
Subcutaneous Tissue ◽  
A Priori ◽  
The Other ◽  
Biological Behavior ◽  
Great Promise ◽  
White Rats ◽  
Other Hand ◽  
Subcutaneous Inoculation

The analysis of the experiments described above indicates that tumors of the white rat or white mouse inoculated into parenchymatous organs acquire a different biological character from those inoculated subcutaneously. The latter are a great deal more benign in their behavior than human cancer or spontaneous tumors in the same species of animals. Tumors inoculated into organs, on the other hand, are quite identical in their biological behavior with the malignant tumors of animal and man. A conclusion must then be drawn, even a priori, that the method of inoculation into organs is a very important aid in the experimental investigation of cancer. It is true that the method is a great deal more complicated and time-consuming than the ordinary subcutaneous inoculation. The subcutaneous method is satisfactory for a number of cancer problems. One of these is the study of general susceptibility and resistance of the organism of the host to the inoculation of the tumors, and this is a subject of paramount importance in cancer research. On the other hand, the investigations of the writer (10) have shown that an animal may be susceptible to a subcutaneous inoculation of a certain tumor and resist the inoculation of the same tumor into the testicle. Undoubtedly this method of inoculation will reveal the existence of a number of other phenomena. The discovery of specific therapeutic measures is certainly the greatest problem in cancer research. A great deal of work has been done already on the subject, and the latest investigations of Wassermann on the chemotherapy of experimental tumors seem to be of great promise. But here also the therapeutic methods must be tried on animals in which the inoculations of tumor cells have been made into parenchymatous organs before the growths thus treated will have any analogy to human cancer. In this connection one must bear in mind the fact that all the empirical so-called specific cancer remedies, which are continually being devised, are usually successful in treating localized skin cancers and fail utterly in the malignant growths of the internal organs. It is comparatively easy to produce a localized necrosis and softening in a circumscribed growth of the skin and subcutaneous tissue, but whether the same result will be produced on a diffuse and better nourished tumor growing inside of a parenchymatous organ cannot be decided a priori. To determine this it is necessary to have experimental proof on animals in which the tumor was inoculated into organs.

Henry Wade (1876–1955) and Cancer Research: Early Years in the Life of a Pioneer of Urological Surgery

2003 ◽  
Vol 11 (2) ◽  
pp. 81-86 ◽  
Author(s):  
D L Gardner
Keyword(s):  
Cancer Research ◽  
Royal College ◽  
Human Cancer ◽  
Hodgkin’S Disease ◽  
Transplant Rejection ◽  
Early Years ◽  
Royal Infirmary ◽  
Early Form ◽  
Urological Surgery ◽  
Microscopic Studies

This paper describes the microscopic studies of human and experimental cancers made by Henry Wade during the years 1904–9. William Ford Robertson, his mentor, and Wade claimed to have discovered a microbial cause of human cancer. The claim was at once fiercely disputed. Wade turned to the investigation of a transmissible sarcoma of the dog, during which he demonstrated an early form of immune transplant rejection. He also undertook studies of Hodgkin's disease. Later in life, Wade established urological surgery at the Royal Infirmary of Edinburgh and became President of the Royal College of Surgeons of Edinburgh.

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