Alterations in Myocardial Gene Expression as a Basis for Cardiomyopathies and Heart Failure

2008 ◽  
pp. 73-89 ◽  
Author(s):  
Matthew R. Taylor ◽  
Michael R. Bristow
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Myocardial Gene Expression

Distinct Myocardial Gene Expression Signatures in Heart Failure with Preserved Ejection Fraction

2020 ◽  
Vol 26 (10) ◽  
pp. S8-S9
Author(s):  
Virginia S. Hahn ◽  
Hildur Knutsdottir ◽  
Aditi Madan ◽  
Xin Luo ◽  
Kenneth Bedi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Preserved Ejection Fraction ◽  
Gene Expression Signatures ◽  
Myocardial Gene Expression

250 EFFECT OF THYROID HORMONE ON MYOCARDIAL GENE EXPRESSION, HEMODYNAMICS AND EXERCISE IN HEART FAILURE

2005 ◽  
Vol 53 (1) ◽  
pp. S121.4-S121
Author(s):  
M. C. Reed ◽  
B. D. Lowes ◽  
M. Cantu ◽  
W. Minobe ◽  
E. Wolfe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Thyroid Hormone ◽  
Myocardial Gene Expression

Myocardial Gene Expression of Regulators of Myocyte Apoptosis and Myocyte Calcium Homeostasis During Hemodynamic Unloading by Ventricular Assist Devices in Patients With End-Stage Heart Failure

Circulation ◽  
1999 ◽  
Vol 100 (suppl_2) ◽  
Author(s):  
Babett Bartling ◽  
Hendrik Milting ◽  
Heike Schumann ◽  
Dorothea Darmer ◽  
Lativ Arusoglu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Sarcoplasmic Reticulum ◽  
Calcium Homeostasis ◽  
Cardiac Transplantation ◽  
Left Ventricular ◽  
Ventricular Assist ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Myocardial Gene Expression

Background —In patients with end-stage heart failure, characterized by an increased susceptibility to cardiomyocyte apoptosis and a labile cardiomyocyte calcium homeostasis, a ventricular assist device (VAD) is implanted for bridging to cardiac transplantation and results in myocardial unloading. Although phenotype changes in the failing heart are assumed to result from hemodynamic overload, the reversibility of these changes under unloading is unknown. Methods and Results —By use of quantitative reverse-transcription polymerase chain reaction, mRNA expression analyses were performed on left ventricular specimens obtained from 10 nonfailing donor hearts (from 8 patients with dilated cardiomyopathy and 2 patients with coronary heart disease) at the time of VAD implantation and 36 to 169 days later during VAD removal with subsequent cardiac transplantation. In terminally failing hearts before VAD support, left ventricular mRNA analyses revealed increased Pro-ANP, reduced antiapoptotic Bcl-x L and antiapoptotic Fas isoform FasExo6Del, and a decreased ratio of sarcoplasmic reticulum Ca 2+ -ATPase per sarcolemmal Na + -Ca 2+ exchanger in comparison with nonfailing ventricles. After VAD unloading, ventricular transcription of Pro-ANP was immediately normalized, and apoptotic DNA fragmentation was attenuated. In patients with dilated cardiomyopathy, mRNAs of Bcl-x L and FasExo6Del/Fas were enhanced depending on time on VAD. The Bcl-x L mRNA level correlated positively with that of the Bcl-x L protein. Transcription of sarcoplasmic reticulum Ca 2+ -ATPase/Na + -Ca 2+ exchanger demonstrated recovery in only 4 of 10 patients. Conclusions —Mechanical support of the failing heart induces a time-dependent change in myocardial gene expression compatible with a decreased susceptibility to apoptosis.

scholarly journals Evidence for Coregulation of Myocardial Gene Expression by MEF2 and NFAT in Human Heart Failure

2009 ◽  
Vol 2 (3) ◽  
pp. 212-219 ◽  
Author(s):  
Mary E. Putt ◽  
Sridhar Hannenhalli ◽  
Yun Lu ◽  
Philip Haines ◽  
Hareesh R. Chandrupatla ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Human Heart ◽  
Human Heart Failure ◽  
Myocardial Gene Expression

scholarly journals Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure

2008 ◽  
Vol 1 (2) ◽  
pp. 117-125 ◽  
Author(s):  
David R. Fermin ◽  
Ana Barac ◽  
Sangjin Lee ◽  
Sean P. Polster ◽  
Sridhar Hannenhalli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Human Heart ◽  
Human Heart Failure ◽  
Myocardial Gene Expression
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