Development of Nano-Structured Micro-Porous Materials and their Application in Bioprocess-Chemical Process Intensification and Tissue Engineering

2005 ◽  
pp. 171-197 ◽  
Author(s):  
G. Akay ◽  
M.A. Bokhari ◽  
V.J. Byron ◽  
M. Dogru
Keyword(s):  
Tissue Engineering ◽  
Porous Materials ◽  
Chemical Process ◽  
Process Intensification

scholarly journals Smart Porous Multi-Stimulus Polysaccharide-Based Biomaterials for Tissue Engineering

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5286
Author(s):  
Fernando Alvarado-Hidalgo ◽  
Karla Ramírez-Sánchez ◽  
Ricardo Starbird-Perez
Keyword(s):  
Tissue Engineering ◽  
Porous Materials ◽  
In Vitro Regeneration ◽  
Textural Properties ◽  
Host Cells ◽  
Future Research ◽  
Porous Scaffolds ◽  
3D Scaffold ◽  
Stimulation Of

Recently, tissue engineering and regenerative medicine studies have evaluated smart biomaterials as implantable scaffolds and their interaction with cells for biomedical applications. Porous materials have been used in tissue engineering as synthetic extracellular matrices, promoting the attachment and migration of host cells to induce the in vitro regeneration of different tissues. Biomimetic 3D scaffold systems allow control over biophysical and biochemical cues, modulating the extracellular environment through mechanical, electrical, and biochemical stimulation of cells, driving their molecular reprogramming. In this review, first we outline the main advantages of using polysaccharides as raw materials for porous scaffolds, as well as the most common processing pathways to obtain the adequate textural properties, allowing the integration and attachment of cells. The second approach focuses on the tunable characteristics of the synthetic matrix, emphasizing the effect of their mechanical properties and the modification with conducting polymers in the cell response. The use and influence of polysaccharide-based porous materials as drug delivery systems for biochemical stimulation of cells is also described. Overall, engineered biomaterials are proposed as an effective strategy to improve in vitro tissue regeneration and future research directions of modified polysaccharide-based materials in the biomedical field are suggested.

scholarly journals Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Changyong Liu ◽  
Junda Tong ◽  
Jun Ma ◽  
Daming Wang ◽  
Feng Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Low Temperature ◽  
Porous Materials ◽  
Porous Electrodes ◽  
Tissue Engineering Scaffolds ◽  
Material Extrusion ◽  
Low Temperature Deposition ◽  
Wide Range ◽  
Temperature Deposition

Low-temperature deposition manufacturing (LTDM) is a technology that combines material extrusion-based 3D printing and thermally induced phase separation (TIPS) into one process. With this feature, both the merits of 3D printing and TIPS can be incorporated including complex geometries with tailorable ordered macroporous features facilitated by 3D printing and microporous/nanoporous features endowed by TIPS. These macroporous/microporous/nanoporous combined structures are important to some important applications such as tissue engineering scaffolds, porous electrodes for electrochemical energy storage, purification, and filtering applications. However, the unique advantages and potential applications of LTDM have not been fully recognized and exploited yet. In this review, we will discuss the origin, principle, advantages, processes, and machine setup of LTDM technology with an emphasis on its unique advantages in fabricating porous materials. Then, current applications of LTDM including porous tissue engineering scaffolds and emerging porous electrodes for electrochemical storage will be described. The versatility of LTDM including its capability of processing a wide range of materials, multimaterial and gradient structures, and core-shell structures will be introduced. Finally, we will conclude with a perspective and outlook on the future development and applications of LTDM technology.

Preparation of Porous HAW/ß-TCP Ceramics with In Situ Synthesis of HA Whiskers

2010 ◽  
Vol 434-435 ◽  
pp. 617-619
Author(s):  
Qing Feng Zan ◽  
Yao Cong Han ◽  
Li Min Dong ◽  
Chen Wang ◽  
Jie Mo Tian
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Porous Materials ◽  
Bone Tissue ◽  
Phase Content ◽  
Calcium Phosphate Ceramics ◽  
Ceramics Matrix

Adding whiskers to ceramic was a way that has been used to strengthen the ceramics matrix. For porous materials, strength of pore walls was an important factor for strength of the whole materials. Porous calcium phosphate ceramics were always used as scaffolds of bone tissue engineering because of their biocompatible and osteoconductibility. In this work, HA whiskers were born in the porous -TCP ceramic during in situ procedure. The HA whiskers with about 2m for length and 100nm for diameter were observed from SEM photographs of as-fabricated porous HA ceramics, and the phase content was determined by XRD.

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