Parathyroid Hormone-Related Protein and Bone Metastases

2006 ◽  
pp. 27-39
Author(s):  
Robert E. Coleman ◽  
T. J. Martin ◽  
Janine A. Danks ◽  
Michael A. Henderson
Keyword(s):  
Parathyroid Hormone ◽  
Bone Metastases ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein

Expression of parathyroid hormone-related protein and its receptor in bone metastases from prostate cancer

2000 ◽  
Vol 191 (2) ◽  
pp. 170-174 ◽  
Author(s):  
Julie Iddon ◽  
Nigel J. Bundred ◽  
Judith Hoyland ◽  
Sarah E. Downey ◽  
Pauline Baird ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Parathyroid Hormone ◽  
Bone Metastases ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein

Parathyroid hormone-related protein and ezrin are up-regulated in human lung cancer bone metastases

2007 ◽  
Vol 24 (2) ◽  
pp. 107-119 ◽  
Author(s):  
Xiyun Deng ◽  
Sarah H. Tannehill-Gregg ◽  
Murali V. P. Nadella ◽  
Guangchun He ◽  
Andrea Levine ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Parathyroid Hormone ◽  
Bone Metastases ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein

scholarly journals Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone

2005 ◽  
Vol 12 (3) ◽  
pp. 549-583 ◽  
Author(s):  
G A Clines ◽  
T A Guise
Keyword(s):  
Parathyroid Hormone ◽  
Bone Metastases ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Major Public Health Problem ◽  
Related Protein ◽  
Vicious Cycle ◽  
Parathyroid Hormone Related Protein ◽  
Osteolytic Bone Disease

Calcium homeostasis is a tightly regulated process involving the co-ordinated efforts of the skeleton, kidney, parathyroid glands and intestine. Neoplasms can alter this homeostasis indirectly through the production of endocrine factors resulting in humoral hypercalcaemia of malignancy. Relatively common with breast and lung cancer, this paraneoplastic condition is most often due to tumour production of parathyroid hormone-related protein and ensuing increased osteoclastic bone resorption. Although control of hypercalcaemia is generally successful, the development of this complication is associated with a poor prognosis. The metastasis of tumour cells to bone represents another skeletal complication of malignancy. As explained in the ‘seed and soil’ hypothesis, bone represents a fertile ground for cancer cells to flourish. The molecular mechanisms of this mutually beneficial relationship between bone and cancer cells are beginning to be understood. In the case of osteolytic bone disease, tumour-produced parathyroid hormone-related protein stimulates osteoclasts that in turn secrete tumour-activating transforming growth factor-β that further stimulates local cancer cells. This ‘vicious cycle’ of bone metastases represents reciprocal bone/cancer cellular signals that likely modulate osteoblastic bone metastatic lesions as well. The development of targeted therapies to either block initial cancer cell chemotaxis, invasion and adhesion or to break the ‘vicious cycle’ is dependent on a more complete understanding of bone metastases. Although bisphosphonates delay progression of skeletal metastases, it is clear that more effective therapies are needed. Cancer-associated bone morbidity remains a major public health problem, and to improve therapy and prevention it is important to understand the pathophysiology of the effects of cancer on bone. This review will detail scientific advances regarding this area.

Parathyroid hormone-related protein (PTHrp) expression in human bone metastases (BM)

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9696-9696 ◽  
Author(s):  
L. Costa ◽  
A. Fernandes ◽  
A. G. Oliveira ◽  
K. Leitzel ◽  
S. Ali ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Metastases ◽  
Human Bone ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Pthrp Expression

scholarly journals Parathyroid Hormone-Related Protein Production by Breast Cancers, Improved Survival, and Reduced Bone Metastases

2001 ◽  
Vol 93 (3) ◽  
pp. 234-237 ◽  
Author(s):  
M. A. Henderson ◽  
J. A. Danks ◽  
J. M. Moseley ◽  
J. L. Slavin ◽  
T. L. Harris ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Metastases ◽  
Protein Production ◽  
Breast Cancers ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein
Sign in / Sign up

Export Citation Format

Share Document