Androgen receptor and molecular mechanisms of male-specific gene expression

2008 ◽  
pp. 42-56 ◽  
Author(s):  
Diane M. Robins
Keyword(s):  
Gene Expression ◽  
Androgen Receptor ◽  
Molecular Mechanisms ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Male Specific

A novel approach to sexing bovine blastocysts using male-specific gene expression

2012 ◽  
Vol 77 (8) ◽  
pp. 1587-1596 ◽  
Author(s):  
C.K. Hamilton ◽  
A. Combe ◽  
J. Caudle ◽  
F.A. Ashkar ◽  
A.D. Macaulay ◽  
...  
Keyword(s):  
Gene Expression ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Novel Approach ◽  
Male Specific

scholarly journals The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice

2006 ◽  
Vol 37 (2) ◽  
pp. 301-316 ◽  
Author(s):  
Andreas Petri ◽  
Jonas Ahnfelt-Rønne ◽  
Klaus Stensgaard Frederiksen ◽  
David George Edwards ◽  
Dennis Madsen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Microarray Analysis ◽  
Molecular Mechanisms ◽  
Homeobox Gene ◽  
Specific Gene ◽  
Wild Type ◽  
Specific Gene Expression ◽  
And Function ◽  
Deficient Mice

To understand the molecular mechanisms regulating pancreatic endocrine development and function, pancreatic gene expression was compared between Ngn3-deficient mice and littermate controls on embryonic days 13 and 15. Microarray analysis identified 504 genes with significant differences in expression. Fifty-two of these showed at least twofold reduction in Ngn3 knockouts compared to controls. Many of them were previously described to be involved in endocrine development and function. Among the genes not previously characterized were Rhomboid veinlet-like 4, genes involved in tetrahydrobiopterin biosynthesis and the Iroquois-type homeobox gene Irx1, the latter was selected for further investigation. In situ hybridisation demonstrated that two Iroquois genes, Irx1 and Irx2, were expressed in pancreatic endoderm of wild-type, but not Ngn3 mutant embryos. Furthermore, ectopic Ngn3 induced prominent Irx2 expression in chicken endoderm. Co-labelling established that Irx1 and Irx2 mRNA is located to glucagon-, but not insulin- or somatostatin-producing cells in mice and chicken. These data suggest that Irx1 and Irx2 serve an evolutionary conserved role in the regulation of α-cell-specific gene expression.

Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad

Development ◽  
1999 ◽  
Vol 126 (13) ◽  
pp. 2883-2890 ◽  
Author(s):  
C. Tilmann ◽  
B. Capel
Keyword(s):  
Gene Expression ◽  
Cell Migration ◽  
Single Gene ◽  
Expression Patterns ◽  
Critical Role ◽  
Cell Types ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Male Specific ◽  
Testis Cord

In mammals a single gene on the Y chromosome, Sry, controls testis formation. One of the earliest effects of Sry expression is the induction of somatic cell migration from the mesonephros into the XY gonad. Here we show that mesonephric cells are required for cord formation and male-specific gene expression in XY gonads in a stage-specific manner. Culturing XX gonads with an XY gonad at their surface, as a ‘sandwich’, resulted in cell migration into the XX tissue. Analysis of sandwich gonads revealed that in the presence of migrating cells, XX gonads organized cord structures and acquired male-specific gene expression patterns. From these results, we conclude that mesonephric cell migration plays a critical role in the formation of testis cords and the differentiation of XY versus XX cell types.

scholarly journals Drosophila Sister-of-Sex-lethal reinforces a male-specific gene expression pattern by controlling Sex-lethal alternative splicing

2018 ◽  
Vol 47 (5) ◽  
pp. 2276-2288 ◽  
Author(s):  
Rebecca Moschall ◽  
Mathias Rass ◽  
Oliver Rossbach ◽  
Gerhard Lehmann ◽  
Lars Kullmann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alternative Splicing ◽  
Expression Pattern ◽  
Gene Expression Pattern ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Sex Lethal ◽  
Male Specific

scholarly journals Network Analysis Identifies Sex-Specific Gene Expression Changes in Blood of Amyotrophic Lateral Sclerosis Patients

2021 ◽  
Vol 22 (13) ◽  
pp. 7150
Author(s):  
Jose A. Santiago ◽  
James P. Quinn ◽  
Judith A. Potashkin
Keyword(s):  
Gene Expression ◽  
Amyotrophic Lateral Sclerosis ◽  
Molecular Mechanisms ◽  
Expression Patterns ◽  
Specific Gene ◽  
Ampk Signaling ◽  
Specific Gene Expression ◽  
Als Patients ◽  
Functional Analyses ◽  
Lateral Sclerosis

Understanding the molecular mechanisms underlying the pathogenesis of amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is a major challenge. We used co-expression networks implemented by the SWitch Miner software to identify switch genes associated with drastic transcriptomic changes in the blood of ALS patients. Functional analyses revealed that switch genes were enriched in pathways related to the cell cycle, hepatitis C, and small cell lung cancer. Analysis of switch genes by sex revealed that switch genes from males were associated with metabolic pathways, including PI3K-AKT, sphingolipid, carbon metabolism, FOXO, and AMPK signaling. In contrast, female switch genes related to infectious diseases, inflammation, apoptosis, and atherosclerosis. Furthermore, eight switch genes showed sex-specific gene expression patterns. Collectively, we identified essential genes and pathways that may explain sex differences observed in ALS. Future studies investigating the potential role of these genes in driving disease disparities between males and females with ALS are warranted.

scholarly journals The transcriptome of the avian malaria parasite Plasmodium ashfordi displays host-specific gene expression

2016 ◽  
Author(s):  
Elin Videvall ◽  
Charlie K. Cornwallis ◽  
Dag Ahrén ◽  
Vaidas Palinauskas ◽  
Gediminas Valkiūnas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Malaria Parasite ◽  
Avian Malaria ◽  
Molecular Mechanisms ◽  
Gene Evolution ◽  
Expression Profiles ◽  
Specific Gene ◽  
Malaria Parasites ◽  
Specific Gene Expression ◽  
Avian Malaria Parasite

AbstractMalaria parasites (Plasmodium spp.) include some of the world’s most widespread and virulent pathogens. Our knowledge of the molecular mechanisms these parasites use to invade and exploit hosts other than mice and primates is, however, extremely limited. It is therefore imperative to characterize transcriptome-wide gene expression from non-model malaria parasites and how this varies across host individuals. Here, we used high-throughput Illumina RNA-sequencing on blood from wild-caught Eurasian siskins experimentally infected with a clonal strain of the avian malaria parasite Plasmodium ashfordi (lineage GRW2). By using a multi-step approach to filter out host transcripts, we successfully assembled the blood-stage transcriptome of P. ashfordi. A total of 11 954 expressed transcripts were identified, and 7 860 were annotated with protein information. We quantified gene expression levels of all parasite transcripts across three hosts during two infection stages – peak and decreasing parasitemia. Interestingly, parasites from the same host displayed remarkably similar expression profiles during different infection stages, but showed large differences across hosts, indicating that P. ashfordi may adjust its gene expression to specific host individuals. We further show that the majority of transcripts are most similar to the human parasite Plasmodium falciparum, and a large number of red blood cell invasion genes were discovered, suggesting evolutionary conserved invasion strategies between mammalian and avian Plasmodium. The transcriptome of P. ashfordi and its host-specific gene expression advances our understanding of Plasmodium plasticity and is a valuable resource as it allows for further studies analysing gene evolution and comparisons of parasite gene expression.

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