Bariatric Surgery for Patients With Early-Onset vs Late-Onset Type 2 Diabetes

JAMA Surgery ◽  
2016 ◽  
Vol 151 (9) ◽  
pp. 798 ◽  
Author(s):  
Lwin Aung ◽  
Wei-Jei Lee ◽  
Shu Chun Chen ◽  
Kong-Han Ser ◽  
Chun-Chi Wu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Early Onset ◽  
Late Onset ◽  
Onset Type

Comparisons of the outcomes on control, type of management and complications status in early onset and late onset type 2 diabetes in Asia

2006 ◽  
Vol 71 (2) ◽  
pp. 146-155 ◽  
Author(s):  
Lee-Ming Chuang ◽  
Sidartawan Soegondo ◽  
Pradana Soewondo ◽  
Kim Young-Seol ◽  
Mafauzy Mohamed ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Late Onset ◽  
Onset Type ◽  
Type Of Management

scholarly journals GLP1R Rs3765467 Polymorphism Is Associated With The Risk Of Early-Onset Type 2 Diabetes

2022 ◽  
Author(s):  
Yunyun Fang ◽  
Jingjing Zhang ◽  
Linlin Ji ◽  
Chaoyu Zhu ◽  
Yuanyuan Xiao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Allele Frequency ◽  
Body Mass ◽  
Early Onset ◽  
Late Onset ◽  
Control Group ◽  
Genotype Distribution ◽  
Onset Type

Abstract Objective: To investigate the relationship between glucagon-like peptide-1 receptor (GLP1R) gene polymorphisms and susceptibility to early-onset type 2 diabetes (EOD).Methods: Samples from 316 type 2 diabetes (T2DM) patients with EOD (n = 137) and late-onset T2DM (n = 179) and 145 non-diabetic individuals were analyzed. Multiplex PCR combined with resequencing HI-Reseq technology was used to detect single nucleotide polymorphisms (SNPs) of the GLP1R gene, and the allele frequency, genotype distribution, and clinical parameters were analyzed between each diabetes subgroup and the control group.Results: Sixteen SNPs were identified in the exonic region of the GLP1R gene according to the minor allele frequency (MAF > 0.05) in the participants. Among these, the GLP1R rs3765467 (G→A) mutation was statistically associated with EOD. Compared with that of the GG carriers, carriers of genotype AA at rs3765467 had a decreased risk of EOD after adjusting for sex and body mass index. In the dominant model, the frequencies of the rs3765467 AA+GA genotype were significantly decreased in the EOD group, and carriers of genotype AA+GA at rs3765467 had a decreased risk of EOD after adjusting for sex and body mass index. Moreover, fasting c peptide levels were significantly higher in GA+AA genotype carriers than that in GG genotype carriers.Conclusion: The GLP1R rs3765467 polymorphism was significantly associated with the age at T2DM diagnosis, and thus may be used as a marker to screen and detect individuals at risk of developing EOD.The name of the clinical trials registry: Exploration of early warning indicators for diabetic chronic complications. The approval number is 2016-004.The approval date is June 12, 2016.

Vitamin D concentrations from neonatal dried blood spots and the risk of early-onset type 2 diabetes in the Danish D-tect case-cohort study

Diabetologia ◽  
2021 ◽  
Author(s):  
Amélie Keller ◽  
Fanney Thorsteinsdottir ◽  
Maria Stougaard ◽  
Isabel Cardoso ◽  
Peder Frederiksen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Cohort Study ◽  
Early Onset ◽  
Dried Blood Spots ◽  
Onset Type ◽  
Blood Spots

scholarly journals Missense mutations in theTGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes

2007 ◽  
Vol 28 (11) ◽  
pp. 1150-1150 ◽  
Author(s):  
O. Porzio ◽  
O. Massa ◽  
V. Cunsolo ◽  
C. Colombo ◽  
M. Malaponti ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Early Onset ◽  
Transglutaminase 2 ◽  
Missense Mutations ◽  
Gene Encoding ◽  
Onset Type

HNF-4α: from MODY to late-onset type 2 diabetes

2004 ◽  
Vol 10 (11) ◽  
pp. 521-524 ◽  
Author(s):  
Rana K. Gupta ◽  
Klaus H. Kaestner
Keyword(s):  
Type 2 Diabetes ◽  
Late Onset ◽  
Onset Type

scholarly journals Preliminary analysis of immune activation in early onset type 2 diabetes

2013 ◽  
Vol 72 (1) ◽  
pp. 21190 ◽  
Author(s):  
Julia D. Rempel ◽  
Juliet Packiasamy ◽  
Heather J. Dean ◽  
Jonathon McGavock ◽  
Alyssa Janke ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Immune Activation ◽  
Early Onset ◽  
Preliminary Analysis ◽  
Onset Type

Distinct Predictors and Comorbidities in Early Onset Type 2 Diabetes Mellitus Among Asian Indians

2017 ◽  
Vol 15 (9) ◽  
pp. 458-464 ◽  
Author(s):  
Gadadharan Vijayakumar ◽  
Ganapathy K. Sreehari ◽  
Aswathi Vijayakumar ◽  
Abdul Jaleel
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Early Onset ◽  
Asian Indians ◽  
Onset Type
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