scholarly journals Evaluation of Variability in Inhaled Nitric Oxide Use and Pulmonary Hypertension in Patients With Congenital Diaphragmatic Hernia

2016 ◽  
Vol 170 (12) ◽  
pp. 1188 ◽  
Author(s):  
Luke R. Putnam ◽  
Kuojen Tsao ◽  
Francesco Morini ◽  
Pamela A. Lally ◽  
Charles C. Miller ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Inhaled Nitric Oxide

Inhaled Nitric Oxide Is Associated with Improved Oxygenation in a Subpopulation of Infants with Congenital Diaphragmatic Hernia and Pulmonary Hypertension

2020 ◽  
Vol 219 ◽  
pp. 167-172 ◽  
Author(s):  
Kendall M. Lawrence ◽  
Stylianos Monos ◽  
Samantha Adams ◽  
Lisa Herkert ◽  
William H. Peranteau ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Inhaled Nitric Oxide

scholarly journals The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e032122 ◽  
Author(s):  
Suzan Cochius-den Otter ◽  
Thomas Schaible ◽  
Anne Greenough ◽  
Arno van Heijst ◽  
Neil Patel ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Randomised Controlled Trial ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Primary Outcome ◽  
Human Subjects ◽  
Controlled Trial ◽  
Inhaled Nitric Oxide ◽  
Randomised Controlled

IntroductionCongenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality. Different therapies are still mainly based on ‘trial and error’. Inhaled nitric oxide (iNO) is often the drug of first choice. However, iNO does not seem to improve mortality. Intravenous sildenafil has reduced mortality in newborns with PH without CDH, but prospective data in CDH patients are lacking.Methods and analysisIn an open label, multicentre, international randomised controlled trial in Europe, Canada and Australia, 330 newborns with CDH and PH are recruited over a 4-year period (2018–2022). Patients are randomised for intravenous sildenafil or iNO. Sildenafil is given in a loading dose of 0.4 mg/kg in 3 hours; followed by continuous infusion of 1.6 mg/kg/day, iNO is dosed at 20 ppm. Primary outcome is absence of PH on day 14 without pulmonary vasodilator therapy and/or absence of death within the first 28 days of life. Secondary outcome measures include clinical and echocardiographic markers of PH in the first year of life. We hypothesise that sildenafil gives a 25% reduction in the primary outcome from 68% to 48% on day 14, for which a sample size of 330 patients is needed. An intention-to-treat analysis will be performed. A p-value (two-sided) <0.05 is considered significant in all analyses.Ethics and disseminationEthics approval has been granted by the ethics committee in Rotterdam (MEC-2017-324) and the central Committee on Research Involving Human Subjects (NL60229.078.17) in the Netherlands. The principles of the Declaration of Helsinki, the Medical Research Involving Human Subjects Act and the national rules and regulations on personal data protection will be used. Parental informed consent will be obtained.Trial registration numberNTR6982; Pre-results.

Inhaled nitric oxide with early surgery improves the outcome of antenatally diagnosed congenital diaphragmatic hernia

2002 ◽  
Vol 37 (8) ◽  
pp. 1188-1190 ◽  
Author(s):  
Hiroomi Okuyama ◽  
Akio Kubota ◽  
Takaharu Oue ◽  
Seika Kuroda ◽  
Ryouichi Ikegami ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Inhaled Nitric Oxide ◽  
Early Surgery

Congenital Diaphragmatic Hernia: Experience with Preoperative Stabilization and Delayed Surgery without ECMO and Inhaled Nitric Oxide

1998 ◽  
Vol 15 (08) ◽  
pp. 487-490 ◽  
Author(s):  
Muneef Al-Hathal ◽  
Stanley Crankson ◽  
Fahad Al-Harbi ◽  
Gasudraz Ahmed ◽  
Khalil Tawil
Keyword(s):  
Nitric Oxide ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Inhaled Nitric Oxide ◽  
Delayed Surgery

Inhaled nitric oxide improved survival in high-risk congenital diaphragmatic hernia

2000 ◽  
Vol 70 ◽  
pp. D36-D36
Author(s):  
Z. Stranák ◽  
J. Janota ◽  
K. Pycha ◽  
J. Snajdauf ◽  
M. Rygl ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
High Risk ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Inhaled Nitric Oxide

Inhaled nitric oxide in congenital diaphragmatic hernia

1994 ◽  
Vol 29 (8) ◽  
pp. 1010-1015 ◽  
Author(s):  
Nishit Shah ◽  
Timothy Jacob ◽  
Renee Exler ◽  
Stephen Morrow ◽  
Henri Ford ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Inhaled Nitric Oxide
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