scholarly journals Association of Definition of Acute Kidney Injury by Cystatin C Rise With Biomarkers and Clinical Outcomes in Children Undergoing Cardiac Surgery

2015 ◽  
Vol 169 (6) ◽  
pp. 583 ◽  
Author(s):  
Michael Zappitelli ◽  
Jason H. Greenberg ◽  
Steven G. Coca ◽  
Catherine D. Krawczeski ◽  
Simon Li ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Clinical Outcomes ◽  
Cystatin C ◽  
Kidney Injury ◽  
Definition Of

scholarly journals Early postoperative serum cystatin C predicts severe acute kidney injury following pediatric cardiac surgery

2011 ◽  
Vol 80 (6) ◽  
pp. 655-662 ◽  
Author(s):  
Michael Zappitelli ◽  
Catherine D. Krawczeski ◽  
Prasad Devarajan ◽  
Zhu Wang ◽  
Kyaw Sint ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cystatin C ◽  
Kidney Injury ◽  
Pediatric Cardiac Surgery ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Postoperative Serum

scholarly journals Routine Adoption of TIMP2 and IGFBP7 Biomarkers in Cardiac Surgery for Early Identification of Acute Kidney Injury

2017 ◽  
Vol 40 (12) ◽  
pp. 714-718 ◽  
Author(s):  
Chiara Levante ◽  
Fiorenza Ferrari ◽  
Chiara Manenti ◽  
Faeq Husain-Syed ◽  
Marta Scarpa ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Clinical Outcomes ◽  
Kidney Injury ◽  
Multivariate Logistic Regression Model ◽  
High Risk Population ◽  
Diagnostic Strategies ◽  
Patients At Risk ◽  
Clinical Interest ◽  
Negative Impacts

Background and purpose Acute Kidney Injury (AKI) is a severe complication affecting many hospitalized patients after cardiac surgery, with negative impacts on short- and long-term clinical outcomes and on healthcare costs. Recently, clinical interest has been aimed at defining and classifying AKI, identifying risk factors and developing diagnostic strategies to identify patients at risk early on. Achieving an early and accurate diagnosis of AKI is a crucial issue, because prevention and timely detection may help to prevent negative clinical outcomes and avoid AKI-associated costs. In this retrospective study, we evaluate the NephroCheck Test as a diagnostic tool for early detection of AKI in a high-risk population of patients undergoing cardiac surgery at the San Bortolo Hospital of Vicenza. Methods We assessed the ability of the NephroCheck Test to predict the probability of developing CSA-AKI (cardiac surgery-associated AKI) and evaluated its accuracy as a diagnostic test, by building a multivariate logistic regression model for CSA-AKI prediction. Results Based on our findings, when the results of the NephroCheck Test are included in a multivariate model its performance is substantially improved, as compared to the benchmark model, which only accounts for the other clinical factors. We also define a rule – in terms of a probability cut-off – for discriminating cases that are at higher risk of developing AKI of any stage versus those in which AKI is less likely. Conclusions Our study has implications in clinical practice: when a Nephrocheck Test result is >0.3 ng/dL, an automated electronic alert prompts the physician to intervene by following a checklist of preventive measures.

scholarly journals Association between mineral and bone disorder in patients with acute kidney injury following cardiac surgery and adverse outcomes

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Tianye Yang ◽  
Wenji Wang ◽  
Xiao Tang ◽  
Peng Shi ◽  
Lulu Zhang ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Clinical Outcomes ◽  
Fibroblast Growth Factor 23 ◽  
Kidney Injury ◽  
Adverse Outcomes ◽  
Tartrate Resistant Acid Phosphatase ◽  
Mineral And Bone Disorder ◽  
Bone Specific Alkaline Phosphatase ◽  
Increased Risk

Abstract Background Numerous studies have evaluated the prevalence and importance of mineral and bone disorders among patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, little is known about dysregulated mineral and bone metabolism in acute kidney injury (AKI). Methods We evaluated the association between mineral and bone metabolites and clinical outcomes in 158 patients who underwent cardiac surgery and developed AKI between June 2014 and January 2016. The baseline characteristics of the patients were recorded, and the levels of mineral and bone metabolites, including calcium, phosphate, intact parathyroid hormone (iPTH), 25-hydroxyvitamin D (25D), bone-specific alkaline phosphatase (BAP), tartrate-resistant acid phosphatase 5b (TRACP-5b) and C-terminal fibroblast growth factor 23 (cFGF23) were measured within 12 h after establishing the clinical diagnosis. Results The serum phosphate, iPTH and cFGF23 levels were significantly associated with the 28-day mortality (phosphate: Hazard Ratio [HR] =2.620, 95% CI: 1.083 to 6.338, p = 0.035; iPTH: HR = 1.044, 95% CI: 1.001 to 1.090, p = 0.046; cFGF23: HR = 1.367, 95% CI: 1.168 to 1.599, p < 0.001). Moreover, higher serum cFGF23 and BAP levels were independently associated with an increased risk of adverse outcomes. Additionally, we found that the serum cFGF23 levels rose most significantly and were associated with the severity of AKI (P < 0.001). Conclusions Mineral and bone metabolites are dysregulated and are associated with adverse clinical outcomes among patients with AKI. Trial registration www.clinicaltrials.gov NCT 00953992. Registered 6 August 2009.

scholarly journals Urinary Cystatin C and Acute Kidney Injury After Cardiac Surgery

2013 ◽  
Vol 61 (5) ◽  
pp. 730-738 ◽  
Author(s):  
Jay L. Koyner ◽  
Amit X. Garg ◽  
Michael G. Shlipak ◽  
Uptal D. Patel ◽  
Kyaw Sint ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cystatin C ◽  
Kidney Injury ◽  
Urinary Cystatin C
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