scholarly journals Sampling Serum in Patients With Vitiligo to Measure Disease Activity in the Skin

2016 ◽  
Vol 152 (11) ◽  
pp. 1187 ◽  
Author(s):  
Mehdi Rashighi ◽  
John E. Harris
Keyword(s):  
Disease Activity ◽  
Measure Disease Activity

Optimal Frequency of Visits for Patients with Systemic Lupus Erythematosus to Measure Disease Activity Over Time

2010 ◽  
Vol 38 (1) ◽  
pp. 60-63 ◽  
Author(s):  
DOMINIQUE IBAÑEZ ◽  
DAFNA D. GLADMAN ◽  
ZAHI TOUMA ◽  
MANDANA NIKPOUR ◽  
MURRAY B. UROWITZ
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Activity Index ◽  
Disease Activity Index ◽  
Systemic Lupus ◽  
The Mean ◽  
Over Time ◽  
Measure Disease Activity ◽  
Lupus Disease Activity

Objective.Adjusted mean Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; AMS) measures lupus disease activity over time. Our aim was to determine optimal visit frequency for calculating AMS.Methods.Patients followed monthly for 12 consecutive visits were included. AMS was calculated using all of the SLEDAI 2000 (AMSGOLD using all 12 visits), only quarterly visits (AMS3, using visits 3 months apart), semiannual visits (AMS6, using first, middle, and last visits only), and annual visits (AMS12, using only the first and last visits). Comparisons of AMS3, AMS6, and AMS12 with AMSGOLD are made using descriptive statistics.Results.Seventy-eight patients were included (92% women, mean age at SLE diagnosis 30.1 yrs and at study start 46.2 yrs). The mean (SD) AMSGOLD for the entire year was 2.05 (1.66), for AMS3 1.99 (1.65), for AMS6 2.12 (1.87), and for AMS12 2.08 (1.83). Mean (SD) of the absolute differences with AMSGOLD: for AMS3 0.29 (0.33), for AMS6 0.45 (0.59), and for AMS12 0.61 (0.58). Differences that were < 0.5 were considered minimal while those ≥ 1 were deemed important. Comparing AMSGOLD to AMS3, 82% of the differences were minimal and 3% were important. When comparing to AMS6, 68% were minimal and 10% were important, while comparing to AMS12, 50% were minimal and 21% were important.Conclusion.Usual clinic visits occurring quarterly offer a good estimation of disease activity over a 1-year period and are preferred over semiannual and annual visits.

Su1812 - Is Endoscopy Necessary to Measure Disease Activity in Ulcerative Colitis: A Systematic Narrative Review

2018 ◽  
Vol 154 (6) ◽  
pp. S-593-S-594
Author(s):  
Sophie Restellini ◽  
Che-yung Chao ◽  
Omar Kherad ◽  
Myriam Martel ◽  
Alan N. Barkun ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Disease Activity ◽  
Narrative Review ◽  
Measure Disease Activity

scholarly journals Assessment of disease activity in patients with rheumatoid arthritis using optical spectral transmission measurements, a non-invasive imaging technique

2015 ◽  
Vol 75 (3) ◽  
pp. 511-518 ◽  
Author(s):  
M van Onna ◽  
D F Ten Cate ◽  
K L Tsoi ◽  
A J L Meier ◽  
J W G Jacobs ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Joint Inflammation ◽  
Imaging Modalities ◽  
Receiver Operating Curve ◽  
Treat To Target ◽  
Spectral Transmission ◽  
Low Disease Activity ◽  
Non Invasive ◽  
Measure Disease Activity

ObjectivesIn rheumatoid arthritis (RA), treat-to-target strategies require instruments for valid detection of joint inflammation. Therefore, imaging modalities are increasingly used in clinical practice. Optical spectral transmission (OST) measurements are non-invasive and fast and may therefore have benefits over existing imaging modalities. We tested whether OST could measure disease activity validly in patients with RA.MethodsIn 59 patients with RA and 10 patients with arthralgia, OST, joint counts, Disease Activity Score (DAS) 28 and ultrasonography (US) were performed. Additionally, MRI was performed in patients with DAS28<2.6. We developed and validated within the same cohort an algorithm for detection of joint inflammation by OST with US as reference.ResultsAt the joint level, OST and US performed similarly inproximal interphalangeal-joints (area under the receiver-operating curve (AUC) of 0.79, p<0.0001) andmetacarpophalangeal joints (AUC 0.78, p<0.0001). Performance was less similar in wrists (AUC 0.62, p=0.006). On the patient level, OST correlated moderately with clinical examination (DAS28 r=0.42, p=0.001), and US scores (r=0.64, p<0.0001). Furthermore, in patients with subclinical and low disease activity, there was a correlation between OST and MRI synovitis score (RAMRIS (Rheumatoid Arthritis MRI Scoring) synovitis), r=0.52, p=0.005.ConclusionsIn this pilot study, OST performed moderately in the detection of joint inflammation in patients with RA. Further studies are needed to determine the diagnostic performance in a new cohort of patients with RA.

Why and how should we measure disease activity and damage in lupus?

2014 ◽  
Vol 43 (6) ◽  
pp. e151-e156 ◽  
Author(s):  
Joy Feld ◽  
David Isenberg
Keyword(s):  
Disease Activity ◽  
Measure Disease Activity

scholarly journals Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review

2019 ◽  
Vol 17 (2) ◽  
pp. 160-170 ◽  
Author(s):  
Ebby George Simon ◽  
Richard Wardle ◽  
Aye Aye Thi ◽  
Jeanette Eldridge ◽  
Sunil Samuel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Large Bowel ◽  
Fecal Calprotectin ◽  
Measure Disease Activity
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