Posttransfusion hepatitis after open-heart operations. Incidence after the administration of blood from commercial and volunteer donor populations

JAMA ◽  
1970 ◽  
Vol 211 (2) ◽  
pp. 261-265 ◽  
Author(s):  
J. H. Walsh
Keyword(s):  
Open Heart ◽  
Posttransfusion Hepatitis ◽  
Volunteer Donor

Cause and frequency of posttransfusion hepatitis after open-heart surgery

1992 ◽  
Vol 70 (7) ◽  
Author(s):  
H.-J. Schlayer ◽  
T. Peters ◽  
S. Preisler ◽  
H. Berthold ◽  
W. Gerok ◽  
...  
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Posttransfusion Hepatitis

A risk index for the prediction of the incidence of non-A, non-B posttransfusion hepatitis in open-heart surgery patients

1983 ◽  
Vol 12 (2) ◽  
pp. 81-92 ◽  
Author(s):  
Yasuko Nagatsuka ◽  
Hitoshi Ohori ◽  
Atsushi Kanno ◽  
Yasuyuki Abe ◽  
Takao Togoh ◽  
...  
Keyword(s):  
Heart Surgery ◽  
Risk Index ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Posttransfusion Hepatitis

Gamma-globulin in the prophylaxis of posttransfusion hepatitis

JAMA ◽  
1966 ◽  
Vol 196 (6) ◽  
pp. 471-474 ◽  
Author(s):  
P. V. Holland
Keyword(s):  
Gamma Globulin ◽  
Posttransfusion Hepatitis

The Hemostatic Mechanism after Open-Heart Surgery

1978 ◽  
Vol 39 (02) ◽  
pp. 474-487 ◽  
Author(s):  
E R Cole ◽  
F Bachmann ◽  
C A Curry ◽  
D Roby
Keyword(s):  
Extracorporeal Circulation ◽  
Heart Surgery ◽  
Polyacrylamide Gel Electrophoresis ◽  
Open Heart Surgery ◽  
Coagulation System ◽  
Open Heart ◽  
Time Activity ◽  
Post Surgery ◽  
Plasma Fractions ◽  
The Mean

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.

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