Vitamin D Supplementation in Young Infants and Recurrent Wheezing

JAMA ◽  
2018 ◽  
Vol 320 (16) ◽  
pp. 1708 ◽  
Author(s):  
Yuan Gao ◽  
Dorothy Zhang ◽  
Bing Hou
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Recurrent Wheezing ◽  
Young Infants

Vitamin D Supplementation in Young Infants and Recurrent Wheezing—Reply

JAMA ◽  
2018 ◽  
Vol 320 (16) ◽  
pp. 1708 ◽  
Author(s):  
Anna Maria Hibbs ◽  
Carol L. Wagner ◽  
Curtis Tatsuoka
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Recurrent Wheezing ◽  
Young Infants

scholarly journals Prevalence and Correlates of Vitamin D Deficiency among Young South African Infants: A Birth Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1500
Author(s):  
Jabulani R. Ncayiyana ◽  
Leonardo Martinez ◽  
Elizabeth Goddard ◽  
Landon Myer ◽  
Heather J. Zar
Keyword(s):  
Vitamin D ◽  
Child Health ◽  
Vitamin D Deficiency ◽  
Birth Cohort ◽  
Early Life ◽  
Vitamin D Supplementation ◽  
Sub Saharan Africa ◽  
Health Study ◽  
Birth Cohort Study ◽  
Young Infants

Early-life vitamin D deficiency is associated with adverse child health outcomes, but the prevalence of vitamin D deficiency and its correlates in infants remains underexplored, particularly in sub-Saharan Africa. We aimed to investigate the prevalence of vitamin D deficiency and its correlates among young infants in South Africa. This study included 744 infants, aged 6–10 weeks from the Drakenstein Child Health Study, a population-based birth cohort. Infants were categorized into distinct categories based on serum 25(OH)D concentration level including deficient (<50 nmol/L), insufficient (50–74 nmol/L), and sufficient (≥75 nmol/L). Using multivariable Tobit and logistic regression models, we examined the correlates of serum 25(OH)D3 levels. The overall prevalence of vitamin D deficiency was 81% (95% confidence intervals (CI]) 78–83). Multivariable regression analysis showed that serum 25(OH)D3 concentration was independently associated with study site, socioeconomic status, and sex. Birth in winter and breastfeeding were the strongest predictors of lower serum 25(OH)D3 concentration levels. Compared to non-breastfed children, children breastfed were at higher risk of vitamin D deficiency (AOR, 1.96; 95% CI, 1.04–3.67) and breastfeeding for more than one month was associated with greater likelihood of vitamin D deficiency (AOR, 5.40; 95% CI, 2.37–12.32) and lower vitamin D concentrations (−16.22 nmol/L; 95% CI, −21.06, −11.39). Vitamin D deficiency in infants is ubiquitous, under-recognised, and strongly associated with season of birth and breastfeeding in this setting. Nutritional interventions with vitamin D supplementation in national health programs in low- and middle-income countries are urgently needed to improve early-life vitamin D status in infants.

scholarly journals Spiral Fracture in Young Infant Causing a Diagnostic Dilemma: Nutritional Rickets versus Child Abuse

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Sonia Kaushal ◽  
Manish Raisingani ◽  
Raphael David ◽  
Bina Shah
Keyword(s):  
Vitamin D ◽  
Young Infant ◽  
Vitamin D Supplementation ◽  
Psychosocial Assessment ◽  
Diagnostic Dilemma ◽  
Elevated Alkaline Phosphatase ◽  
Spiral Fracture ◽  
Nutritional Rickets ◽  
Young Infants ◽  
Vitamin D Levels

Fractures are uncommon in young, nonambulatory infants. The differential diagnosis includes nonaccidental injury (NAI) and metabolic bone disease, including rickets. While rickets typically present after six months of age, multiple cases have been reported in younger infants. We report a case of an 11-week-old male infant who presented with a spiral fracture of the humerus and no radiologic evidence of rickets. A detailed psychosocial assessment failed to reveal any risk factors for NAI. The patient had elevated alkaline phosphatase and PTH with low 25 hydroxyvitamin D and 1,25 dihydroxyvitamin D levels. Additionally, the mother was noncompliant with prenatal vitamins, exclusively breastfeeding without vitamin D supplementation, and had markedly low vitamin D levels 15 weeks postpartum. The biochemical data and history were consistent with rickets. Given the diagnostic dilemma, the working diagnosis was rickets and the patient was started on ergocalciferol with subsequent normalization of his laboratory values and healing of the fracture. These findings are consistent with nutritional rickets largely due to maternal-fetal hypovitaminosis D. This case highlights that in young infants rickets should be considered even in the absence of positive radiologic findings. Additionally, it illustrates the importance of maintaining adequate vitamin D supplementation during pregnancy and early infancy.

scholarly journals Vitamin D status in exclusively breast-fed infants and their mothers

2018 ◽  
Vol 5 (5) ◽  
pp. 1966
Author(s):  
Vignesh Kumaran C. R. ◽  
Sundari S. ◽  
Shanthi Ramesh
Keyword(s):  
Vitamin D ◽  
Public Awareness ◽  
Public Health Problem ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Tropical Country ◽  
Cross Sectional ◽  
Breastfed Infants ◽  
Young Infants ◽  
Vitamin D Levels

Background: India, despite being a tropical country has widespread vitamin D deficiency across all age groups. Present study was conducted to estimate the prevalence of subclinical hypovitaminosis D in exclusively breastfed infants and their mothers and also to study the correlation between the Vitamin D levels of these infants and their mothers.Methods: This cross-sectional study was conducted in 37 exclusively breastfed infants aged 6 months and below and their mothers.  Under strict aseptic precautions 2 ml of blood was taken from each infant and mother and serum levels of 25(OH) D levels were measured by the direct ELISA method. Statistical analysis was done by using chi-square test, one-way ANOVA f-test and student independent t-test.Results: In present study, authors found that 78.3% of the mothers were Vitamin D deficient and 21.7% of the mothers were Vitamin D insufficient. Among the infants, authors found that 91.9% of the infants were Vitamin D deficient and 8.1% of the infants were Vitamin D insufficient. The association between dietary pattern and socio-economic class and mean maternal vitamin D levels was found to be statistically significant (p <0.05).Conclusions: There is a high prevalence of hypovitaminosis D amongst exclusively breastfed infants and their mothers. Hence, public awareness needs to be created regarding the benefits of sunlight exposure. Vitamin D fortification of food products and routine Vitamin D supplementation program for antenatal and lactating mothers and their young infants may be able to address this emerging public health problem in our country.

scholarly journals Prevalence of vitamin D deficiency and its relationship with factors associated with recurrent wheezing

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Mirna Brito Peçanha ◽  
Rodrigo de Barros Freitas ◽  
Tiago Ricardo Moreira ◽  
Luiz Sérgio Silva ◽  
Leandro Licursi de Oliveira ◽  
...  
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Environmental Pollution ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Personal History ◽  
First Year ◽  
Recurrent Wheezing ◽  
History Of ◽  
First Year Of Life

ABSTRACT Objective: To determine the prevalence of vitamin D deficiency/insufficiency in children 0-18 years of age with recurrent wheezing and/or asthma residing in the microregion of Viçosa, Minas Gerais, Brazil, and treated at a referral center, and to determine its association with major risk factors for wheezing. Methods: A cross-sectional study was performed using a semi-structured questionnaire, which was administered by trained interviewers to the legal guardians of the study participants. Data were obtained regarding general characteristics of recurrent wheezing; general sociodemographic, environmental, and biologic factors; and atopy-related factors. The magnitude of the statistical association was assessed by calculating ORs and their corresponding 95% CIs by using multiple logistic regression. Results: We included 124 children in the study. The prevalence of vitamin D deficiency/insufficiency in the sample was 57.3%. Vitamin D deficiency/insufficiency was found to be associated with wheezing in the first year of life, personal history of atopic dermatitis, environmental pollution, and vitamin D supplementation until 2 years of age. Conclusions: The prevalence of vitamin D deficiency/insufficiency was high in our sample. Vitamin D concentrations were directly associated with vitamin D supplementation until 2 years of age and were inversely associated with wheezing events in the first year of life, personal history of atopic dermatitis, and environmental pollution.

scholarly journals Effect of Vitamin D Supplementation on Recurrent Wheezing in Black Infants Who Were Born Preterm

JAMA ◽  
2018 ◽  
Vol 319 (20) ◽  
pp. 2086 ◽  
Author(s):  
Anna Maria Hibbs ◽  
Kristie Ross ◽  
Leigh Ann Kerns ◽  
Carol Wagner ◽  
Mamta Fuloria ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Supplementation ◽  
Recurrent Wheezing

Profiling older community-dwellers with hypovitaminosis D: A classification tree analysis

2020 ◽  
Vol 90 (3-4) ◽  
pp. 195-199 ◽  
Author(s):  
Gaelle Chevallereau ◽  
Mathilde Legeay ◽  
Guillaume T. Duval ◽  
Spyridon N. Karras ◽  
Bruno Fantino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Classification Tree ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Community Dwelling ◽  
Gait Disorders ◽  
Hydroxyvitamin D ◽  
Chaid Analysis ◽  
Clinical Profiles ◽  
Community Dwellers

Abstract. Despite the high prevalence of hypovitaminosis D in older adults, universal vitamin D supplementation is not recommended due to potential risk of intoxication. Our aim here was to determine the clinical profiles of older community-dwellers with hypovitaminosis D. The perspective is to build novel strategies to screen for and supplement those with hypovitaminosis D. A classification tree (CHAID analysis) was performed on multiple datasets standardizedly collected from 1991 older French community-dwelling volunteers ≥ 65 years in 2009–2012. Hypovitaminosis D was defined as serum 25-hydroxyvitamin D ≤ 50 nmol/L. CHAID analysis retained 5 clinical profiles of older community-dwellers with different risks of hypovitaminosis D up to 87.3%, based on various combinations of the following characteristics: polymorbidity, obesity, sadness and gait disorders. For instance, the probability of hypovitaminosis D was 1.42-fold higher [95CI: 1.27–1.59] for those with polymorbidity and gait disorders compared to those with no polymorbidity, no obesity and no sadness. In conclusion, these easily-recordable measures may be used in clinical routine to identify older community-dwellers for whom vitamin D supplementation should be initiated.

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