Association of a Genetic Risk Score With Body Mass Index—Reply

JAMA ◽  
2016 ◽  
Vol 316 (17) ◽  
pp. 1826
Author(s):  
M. Maria Glymour ◽  
Stefan Walter ◽  
Iván Mejía-Guevara
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score

scholarly journals Association of a Genetic Risk Score With Body Mass Index

JAMA ◽  
2016 ◽  
Vol 316 (17) ◽  
pp. 1825
Author(s):  
Marcus R. Munafò ◽  
Kate Tilling ◽  
George Davey Smith
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score

scholarly journals Association of a Genetic Risk Score With Body Mass Index Across Different Birth Cohorts

JAMA ◽  
2016 ◽  
Vol 316 (1) ◽  
pp. 63 ◽  
Author(s):  
Stefan Walter ◽  
Iván Mejía-Guevara ◽  
Karol Estrada ◽  
Sze Y. Liu ◽  
M. Maria Glymour
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Birth Cohorts

Association of a Genetic Risk Score With Body Mass Index

JAMA ◽  
2016 ◽  
Vol 316 (17) ◽  
pp. 1826
Author(s):  
Hexuan Liu ◽  
Guang Guo
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score

scholarly journals Interaction of a genetic risk score with physical activity, physical inactivity, and body mass index in relation to venous thromboembolism risk

2018 ◽  
Vol 42 (4) ◽  
pp. 354-365 ◽  
Author(s):  
Jihye Kim ◽  
Peter Kraft ◽  
Kaitlin A. Hagan ◽  
Laura B. Harrington ◽  
Sara Lindstroem ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Venous Thromboembolism ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Physical Inactivity ◽  
Genetic Risk Score

scholarly journals Saturated Fat Intake Modulates the Association between an Obesity Genetic Risk Score and Body Mass Index in Two US Populations

2014 ◽  
Vol 114 (12) ◽  
pp. 1954-1966 ◽  
Author(s):  
Patricia Casas-Agustench ◽  
Donna K. Arnett ◽  
Caren E. Smith ◽  
Chao-Qiang Lai ◽  
Laurence D. Parnell ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Saturated Fat ◽  
Fat Intake ◽  
Saturated Fat Intake

scholarly journals Association of a Body Mass Index Genetic Risk Score with Growth throughout Childhood and Adolescence

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e79547 ◽  
Author(s):  
Nicole M. Warrington ◽  
Laura D. Howe ◽  
Yan Yan Wu ◽  
Nicholas J. Timpson ◽  
Kate Tilling ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Childhood And Adolescence

scholarly journals Using a genetic risk score to estimate the earliest age of Alzheimer’s disease-related physiologic change in Body Mass Index

2019 ◽  
Author(s):  
Willa D. Brenowitz ◽  
Scott C. Zimmerman ◽  
Teresa J. Filshtein ◽  
Kristine Yaffe ◽  
Stefan Walter ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Mass Index ◽  
Weight Loss ◽  
Body Mass ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Genetic Ancestry ◽  
Uk Biobank

AbstractObjectivesWeight loss is common in the years before an Alzheimer’s disease (AD) diagnosis, likely due to changes in appetite and diet. The age at which this change in body mass index (BMI) emerges is unclear but may point to the earliest manifestations of AD, timing that may be important for identifying windows of intervention or risk reduction. We examined the association between AD genetic risk and cross-sectional BMI across adults in mid-to late-life as an innovative approach to determine the age at which BMI changes and may indicate preclinical AD.DesignObservational studySettingUK BiobankParticipants407,386 UK Biobank non-demented participants aged 39-70 with Caucasian genetic ancestry enrolled 2007-2010.Main Outcome MeasuresBMI (kg/m2) was constructed from height and weight measured during the initial visit. A genetic risk score for AD (AD-GRS) was calculated as a weighted sum of 23 genetic variants previously confirmed to be genome-wide significant predictors of AD (Z-scored). We evaluated whether the association of AD-GRS with BMI differed by age using linear regression with adjustment for sex and genetic ancestry, stratified by age grouping (40-60, 61+). We calculated the earliest age at which high AD-GRS predicted divergence in BMI compared to normal age-related BMI trends with linear and quadratic terms for age and interactions with AD-GRS.ResultsIn 39-49 year olds, AD-GRS was not significantly associated with lower BMI (0.00 kg/m2 per SD in AD-GRS; 95%CI: -0.03,0.03). In 50-59 year olds AD-GRS was associated with lower BMI (-0.03 kg/m2 per 1 SD in AD-GRS; 95%CI:-0.06,-0.01) and this association was stronger in 60-70 year olds (-0.09 kg/m2 per 1 SD in AD-GRS; 95%CI:-0.12,-0.07). Model-based BMI age-curves for people with high versus low AD-GRS scores began to diverge after age 47.InterpretationGenetic factors that increase AD risk begin to predict lower BMI in adults by age 50, with greater effect later in older ages. Weight loss may manifest as an early pathophysiologic change associated with AD.

scholarly journals Body mass index and depressive symptoms: instrumental-variables regression with genetic risk score

2012 ◽  
pp. n/a-n/a ◽  
Author(s):  
M. Jokela ◽  
M. Elovainio ◽  
L. Keltikangas-Järvinen ◽  
G. D. Batty ◽  
M. Hintsanen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Depressive Symptoms ◽  
Body Mass ◽  
Instrumental Variables ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score
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