Mixed Results for Bone Marrow–Derived Cell Therapy for Ischemic Heart Disease

JAMA ◽  
2012 ◽  
Vol 308 (22) ◽  
pp. 2405 ◽  
Author(s):  
Eduardo Marbán ◽  
Konstantinos Malliaras
Keyword(s):  
Bone Marrow ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Ischemic Heart

Bone Marrow Cell Therapy for Ischemic Heart Disease

2015 ◽  
Vol 117 (6) ◽  
pp. 490-493 ◽  
Author(s):  
Giulio Pompilio ◽  
Patrizia Nigro ◽  
Beatrice Bassetti ◽  
Maurizio C. Capogrossi
Keyword(s):  
Bone Marrow ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Bone Marrow Cell ◽  
Marrow Cell ◽  
Ischemic Heart ◽  
Bone Marrow Cell Therapy

Bone marrow-derived stem cell therapy in ischemic heart disease

2006 ◽  
Vol 1 (3) ◽  
pp. 337-345 ◽  
Author(s):  
Hyun-Jai Cho ◽  
Juyong Lee ◽  
Andrea Wecker ◽  
Young-sup Yoon
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Stem Cell Therapy ◽  
Ischemic Heart

scholarly journals Cell Therapy in Ischemic Heart Disease: Interventions That Modulate Cardiac Regeneration

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Maximiliano I. Schaun ◽  
Bruna Eibel ◽  
Melissa Kristocheck ◽  
Grasiele Sausen ◽  
Luana Machado ◽  
...  
Keyword(s):  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Adult Stem Cells ◽  
Therapeutic Potential ◽  
Cardiac Regeneration ◽  
Current Data ◽  
Ischemic Heart ◽  
Promising Alternative ◽  
Clinical Conditions

The incidence of severe ischemic heart disease caused by coronary obstruction has progressively increased. Alternative forms of treatment have been studied in an attempt to regenerate myocardial tissue, induce angiogenesis, and improve clinical conditions. In this context, cell therapy has emerged as a promising alternative using cells with regenerative potential, focusing on the release of paracrine and autocrine factors that contribute to cell survival, angiogenesis, and tissue remodeling. Evidence of the safety, feasibility, and potential effectiveness of cell therapy has emerged from several clinical trials using different lineages of adult stem cells. The clinical benefit, however, is not yet well established. In this review, we discuss the therapeutic potential of cell therapy in terms of regenerative and angiogenic capacity after myocardial ischemia. In addition, we addressed nonpharmacological interventions that may influence this therapeutic practice, such as diet and physical training. This review brings together current data on pharmacological and nonpharmacological approaches to improve cell homing and cardiac repair.

scholarly journals Profoundly Reduced Neovascularization Capacity of Bone Marrow Mononuclear Cells Derived From Patients With Chronic Ischemic Heart Disease

Circulation ◽  
2004 ◽  
Vol 109 (13) ◽  
pp. 1615-1622 ◽  
Author(s):  
Christopher Heeschen ◽  
Ralf Lehmann ◽  
Jörg Honold ◽  
Birgit Assmus ◽  
Alexandra Aicher ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Mononuclear Cells ◽  
Ischemic Heart ◽  
Bone Marrow Mononuclear Cells ◽  
Chronic Ischemic Heart Disease

Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: results from a meta-analysis of large animal studies

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P1462-P1462
Author(s):  
S. J. Jansen Of Lorkeers ◽  
J. E. C. Eding ◽  
T. I. G. Van Der Spoel ◽  
H. M. Vesterinen ◽  
S. Koudstaal ◽  
...  
Keyword(s):  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Animal Studies ◽  
Meta Analysis ◽  
Ischemic Heart ◽  
Large Animal ◽  
Allogeneic Cell ◽  
Allogeneic Cell Therapy

The Safety and Feasibility of the Local Implantation of Autologous Bone Marrow Cells for Ischemic Heart Disease

2003 ◽  
Vol 18 ◽  
pp. S69-S75 ◽  
Author(s):  
Tao-Sheng Li ◽  
Kimikazu Hamano ◽  
Ken Hirata ◽  
Toshiro Kobayashi ◽  
Masahiko Nishida
Keyword(s):  
Bone Marrow ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow ◽  
Ischemic Heart ◽  
Autologous Bone ◽  
Marrow Cells

New strategies for improving stem cell therapy in ischemic heart disease

2016 ◽  
Vol 21 (6) ◽  
pp. 737-752 ◽  
Author(s):  
Peisen Huang ◽  
Xiaqiu Tian ◽  
Qing Li ◽  
Yuejin Yang
Keyword(s):  
Stem Cell ◽  
Heart Disease ◽  
Cell Therapy ◽  
Ischemic Heart Disease ◽  
Stem Cell Therapy ◽  
Ischemic Heart ◽  
New Strategies
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