Cell Phone Activation and Brain Glucose Metabolism

JAMA ◽  
2011 ◽  
Vol 305 (20) ◽  
pp. 2066 ◽  
Author(s):  
Arthur Kosowsky
Keyword(s):  
Glucose Metabolism ◽  
Cell Phone ◽  
Brain Glucose ◽  
Brain Glucose Metabolism

Cell Phone Activation and Brain Glucose Metabolism

JAMA ◽  
2011 ◽  
Vol 305 (20) ◽  
pp. 2066 ◽  
Author(s):  
Christopher C. Davis
Keyword(s):  
Glucose Metabolism ◽  
Cell Phone ◽  
Brain Glucose ◽  
Brain Glucose Metabolism

Cell Phone Activation and Brain Glucose Metabolism

JAMA ◽  
2011 ◽  
Vol 305 (20) ◽  
pp. 2066 ◽  
Author(s):  
Carl-Henrik Nordström
Keyword(s):  
Glucose Metabolism ◽  
Cell Phone ◽  
Brain Glucose ◽  
Brain Glucose Metabolism

scholarly journals The impact of a multi-domain intervention on cerebral glucose metabolism: analysis from the randomized ancillary FDG PET MAPT trial

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Julien Delrieu ◽  
Thierry Voisin ◽  
Laure Saint-Aubert ◽  
Isabelle Carrie ◽  
Christelle Cantet ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Fdg Pet ◽  
Primary Outcome ◽  
Cognitive Stimulation ◽  
Cerebral Glucose Metabolism ◽  
Parahippocampal Gyrus ◽  
Cerebral Magnetic Resonance Imaging ◽  
Brain Glucose ◽  
Brain Glucose Metabolism ◽  
The Impact

Abstract Background The Multidomain Alzheimer Preventive Trial (MAPT) was designed to assess the efficacy of omega-3 fatty acid supplementation, multidomain intervention (MI), or a combination of both on cognition. Although the MAPT study was negative, an effect of MI in maintaining cognitive functions compared to placebo group was showed in positive amyloid subjects. A FDG PET study (MAPT-NI) was implemented to test the impact of MI on brain glucose metabolism. Methods MAPT-NI was a randomized, controlled parallel-group single-center study, exploring the effect of MI on brain glucose metabolism. Participants were non-demented and had memory complaints, limitation in one instrumental activity of daily living, or slow gait. Participants were randomly assigned (1:1) to “MI group” or “No MI group.” The MI consisted of group sessions focusing on 3 domains: cognitive stimulation, physical activity, nutrition, and a preventive consultation. [18F]FDG PET scans were performed at baseline, 6 months, and 12 months, and cerebral magnetic resonance imaging scans at baseline. The primary objective was to evaluate the MI effect on brain glucose metabolism assessed by [18F]FDG PET imaging at 6 months. The primary outcome was the quantification of regional metabolism rate for glucose in cerebral regions involved early in Alzheimer disease by relative semi-quantitative SUVr (FDG-based AD biomarker). An exploratory voxel-wise analysis was performed to assess the effect of MI on brain glucose metabolism without anatomical hypothesis. Results The intention-to-treat population included 67 subjects (34 in the MI group and 33 in the No MI group. No significant MI effect was observed on primary outcome at 6 months. In the exploratory voxel-wise analysis, we observed a difference in favor of MI group on the change of cerebral glucose metabolism in limbic lobe (right hippocampus, right posterior cingulate, left posterior parahippocampal gyrus) at 6 months. Conclusions MI failed to show an effect on metabolism in FDG-based AD biomarker, but exploratory analysis suggested positive effect on limbic system metabolism. This finding could suggest a delay effect of MI on AD progression. Trial registration ClinicalTrials.gov Identifier, NCT01513252.

scholarly journals Highly palatable diet changes brain glucose metabolism in mice

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Sarah Wehle Gehres ◽  
Andreia Silva da Rocha ◽  
Yuri Elias Rodrigues ◽  
Guilherme G Schu Peixoto ◽  
Afonso Kopczynski Carvalho ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Brain Glucose ◽  
Brain Glucose Metabolism ◽  
Palatable Diet ◽  
Highly Palatable Diet
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