Extracorporeal Membrane Oxygenation for ARDS Due to 2009 Influenza A(H1N1)

Extracorporeal membrane oxygenation (ECMO) has been used with increasing frequency to support patients with acute respiratory failure, most commonly, and severe forms of acute respiratory distress syndrome (ARDS). The marked increase in the global use of ECMO followed the publication of a large randomized trial in 2009 and the experience garnered during the 2009 influenza A (H1N1) pandemic, and has been further supported by the release of a large, randomized clinical trial in 2018, confirming a benefit from using ECMO in patients with severe ARDS. Despite a rapid expansion of ECMO-related publications, optimal management of patients receiving ECMO, in terms of patient selection, ventilator management, anticoagulation, and transfusion strategies, is evolving. Most recently, ECMO is being utilized for an expanding variety of conditions, including for cases of severe pulmonary or cardiac failure from coronavirus disease 2019 (COVID-19). This review evaluates modern evidence for ECMO for respiratory failure and the current challenges in the field.

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A child with influenza A (H1N1)-associated myocarditis rescued by extracorporeal membrane oxygenation

Journal of Artificial Organs ◽

10.1007/s10047-010-0523-y ◽

2010 ◽

Vol 13 (4) ◽

pp. 232-234 ◽

Cited By ~ 19

Author(s):

Takeshi Oda ◽

Hiroshi Yasunaga ◽

Yoshimitsu Tsutsumi ◽

Takahiro Shojima ◽

Yasuyuki Zaima ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Influenza A ◽

Membrane Oxygenation ◽

Influenza A H1n1

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Extracorporeal membrane oxygenation in Jehovah’s Witness patients: Case report, literature review, and summary of recommendations

Perfusion ◽

10.1177/02676591211047774 ◽

2021 ◽

pp. 026765912110477

Author(s):

Abrahán Mera ◽

Eduard Argudo ◽

María Martínez-Martínez ◽

Clara Palmada ◽

Camilo Bonilla ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Influenza A ◽

Jehovah’S Witness ◽

Jehovah's Witness ◽

Membrane Oxygenation ◽

Influenza A H1n1 ◽

Refractory Hypoxemia ◽

Venovenous Ecmo ◽

H1n1 Pneumonia ◽

Witness Patient

Extracorporeal Membrane Oxygenation (ECMO) is commonly associated with a high blood transfusion requirement. Jehovah’s Witness patients present a particular challenge. The impossibility of transfusing blood cells and starting anticoagulation treatment are common contraindications for this supportive measure. Here we report the case of a Jehovah’s Witness patient with refractory hypoxemia due to influenza A H1N1 pneumonia who required venovenous ECMO for 11 days. We describe the use of a bloodless approach to reduce the waste of blood, avoiding anticoagulation, and improving red blood cell production. We then summarize the current literature on the use of ECMO in Jehovah’s Witness patients and, finally, we propose some recommendations for their management.

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Life-threatening antineutrophil cytoplasmic antibody–associated vasculitis after influenza A H1N1 infection requiring veno-venous extracorporeal membrane oxygenation

Perfusion ◽

10.1177/0267659120927210 ◽

2020 ◽

Vol 35 (6) ◽

pp. 546-549

Author(s):

Frantzeska G. Frantzeskaki ◽

Stavros Dimopoulos ◽

Dimitrios Konstantonis ◽

Pelagia Katsibri ◽

Kostantinos Kostopanagiotou ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Influenza A ◽

Immunosuppressive Treatment ◽

Pulmonary Hemorrhage ◽

Antineutrophil Cytoplasmic Antibody ◽

H1n1 Infection ◽

Membrane Oxygenation ◽

Antineutrophil Cytoplasmic Autoantibody ◽

Influenza A H1n1 ◽

Life Threatening

Introduction: Antineutrophil cytoplasmic autoantibody–associated vasculitis is an immune-mediated necrotizing vasculitis, affecting small- and medium-sized vessels. Case report: A 22-year-old female patient with free medical history presented with life-threatening pulmonary hemorrhage due to antineutrophil cytoplasmic autoantibody–associated vasculitis, temporarily associated with influenza A H1N1 infection. Due to rapidly worsening respiratory failure, despite conventional management, veno-venous peripheral extracorporeal membrane oxygenation was initiated and continued for 26 days, with subsequent renal replacement therapy. Discussion: We present a case of severe antineutrophil cytoplasmic autoantibody–associated pulmonary vasculitis, managed with veno-venous extracorporeal membrane oxygenation at the initial phase. Despite the significant challenges raised with the use of extracorporeal membrane oxygenation in pulmonary hemorrhage cases, extracorporeal membrane oxygenation may have a significant impact on outcome in this setting, by providing adequate time for a successful immunosuppressive treatment.

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Oxigenação extracorpórea por membrana na hipoxemia grave: hora de revermos nossos conceitos?

Jornal Brasileiro de Pneumologia ◽

10.1590/s1806-37132012000100003 ◽

2012 ◽

Vol 38 (1) ◽

pp. 7-12 ◽

Cited By ~ 3

Author(s):

Luciano Cesar Pontes Azevedo ◽

Marcelo Park ◽

Eduardo Leite Vieira Costa ◽

Edzângela Vasconcelos Santos ◽

Adriana Hirota ◽

...

Keyword(s):

Extracorporeal Membrane Oxygenation ◽

Influenza A ◽

Membrane Oxygenation ◽

Influenza A H1n1

Em 2009, muitos casos de infecção pulmonar com hipoxemia grave refratária às estratégias ventilatórias habitualmente utilizadas e às manobras de resgate para a síndrome do desconforto respiratório agudo foram relatados durante a epidemia por influenza A (H1N1). Em muitos desses pacientes, o uso de extracorporeal membrane oxygenation (ECMO, oxigenação extracorpórea por membrana) foi necessário, fato que fez reacender o interesse na ECMO globalmente. O Grupo De Estudos em Suporte Extracorpóreo foi criado visando a aprender a técnica e a utilizar ECMO no tratamento de pacientes com hipoxemia grave. Neste artigo, são discutidas as indicações de ECMO e é relatado o caso de uma paciente com hipoxemia refratária que foi tratada através de ECMO de forma bem sucedida.

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