scholarly journals Ischemic Basis for Deep White Matter Hyperintensities in Major Depression

2002 ◽  
Vol 59 (9) ◽  
pp. 785 ◽  
Author(s):  
Alan J. Thomas ◽  
John T. O'Brien ◽  
Sue Davis ◽  
Clive Ballard ◽  
Robert Barber ◽  
...  
Keyword(s):  
White Matter ◽  
Major Depression ◽  
White Matter Hyperintensities ◽  
Deep White Matter

Cortical thinning related to periventricular and deep white matter hyperintensities

2012 ◽  
Vol 33 (7) ◽  
pp. 1156-1167.e1 ◽  
Author(s):  
Sang Won Seo ◽  
Jong-Min Lee ◽  
Kiho Im ◽  
Jun-Sung Park ◽  
Sook-Hui Kim ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Deep White Matter ◽  
Cortical Thinning

scholarly journals Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexander Rau ◽  
Marco Reisert ◽  
Elias Kellner ◽  
Jonas A. Hosp ◽  
Horst Urbach ◽  
...  
Keyword(s):  
White Matter ◽  
Water Content ◽  
Normal Pressure Hydrocephalus ◽  
Interstitial Fluid ◽  
White Matter Hyperintensities ◽  
Free Water ◽  
Normal Pressure ◽  
Idiopathic Normal Pressure Hydrocephalus ◽  
Imaging Features ◽  
Deep White Matter

AbstractPeriventricular white matter changes are common in patients with idiopathic normal pressure hydrocephalus (iNPH) and considered to represent focally elevated interstitial fluid. We compared diffusion measures in periventricular hyperintensities in patients with imaging features of iNPH to patients without. The hypothesis is that periventricular hyperintensities in patients with presumed iNPH show higher water content than in patients without imaging features of iNPH. 21 patients with iNPH Radscale 7–12 (“high probability of iNPH”) and 10 patients with iNPH Radscale 2–4 (“low probability of iNPH”) were examined with a neurodegeneration imaging protocol including a diffusion microstructure imaging sequence. Periventricular hyperintensities and deep white matter hyperintensities were segmented and diffusion measures were compared. In patients with imaging features of iNPH, the free water content in periventricular hyperintensities was significantly higher compared to the control group (p = 0.005). This effect was also detectable in deep white matter hyperintensities (p = 0.024). Total brain volumes and total gray or white matter volumes did not differ between the groups. Periventricular cap free water fraction was highly discriminative regarding patients with presumed iNPH and controls with an ROC AUC of 0.933. Quantitative diffusion microstructure imaging shows elevated water content in periventricular hyperintensities in patients with imaging features of iNPH, which could be the imaging correlate for pathologic fluid accumulation and may be used as an imaging biomarker in the future.

scholarly journals Laterality of deep white matter hyperintensities correlates with basilar artery bending and vertebral artery dominance

2021 ◽  
Vol 62 (4) ◽  
pp. 360-366
Author(s):  
Laszlo Szalontai ◽  
Zsofia Jokkel ◽  
Tamas Horvath ◽  
Bianka Forgo ◽  
Ildiko Kalina ◽  
...  
Keyword(s):  
White Matter ◽  
Vertebral Artery ◽  
Basilar Artery ◽  
White Matter Hyperintensities ◽  
Deep White Matter

scholarly journals Handgrip Strength Is Associated With Hippocampal Volume and White Matter Hyperintensities in Major Depression and Healthy Controls

2020 ◽  
Vol 82 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Josh A. Firth ◽  
Lee Smith ◽  
Jerome Sarris ◽  
Davy Vancampfort ◽  
Felipe Schuch ◽  
...  
Keyword(s):  
White Matter ◽  
Major Depression ◽  
White Matter Hyperintensities ◽  
Handgrip Strength ◽  
Hippocampal Volume ◽  
Healthy Controls
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