scholarly journals Novel Panel of Cerebrospinal Fluid Biomarkers for the Prediction of Progression to Alzheimer Dementia in Patients With Mild Cognitive Impairment

2007 ◽  
Vol 64 (3) ◽  
pp. 366 ◽  
Author(s):  
Anja H. Simonsen ◽  
James McGuire ◽  
Oskar Hansson ◽  
Henrik Zetterberg ◽  
Vladimir N. Podust ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Dementia ◽  
Cerebrospinal Fluid Biomarkers

scholarly journals Unique Sleep and Circadian Rhythm Dysfunction Neuroinflammatory and Immune Profiles in Alzheimer’s Disease with Mild Cognitive Impairment

2021 ◽  
pp. 1-6
Author(s):  
Jagan A. Pillai ◽  
James Bena ◽  
Lynn M. Bekris ◽  
Nancy Foldvary-Schaefer ◽  
Catherine Heinzinger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Circadian Rhythm ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Cerebrospinal Fluid Biomarkers ◽  
Circulating Markers

Sleep dysfunction has been identified in the pathophysiology of Alzheimer’s disease (AD); however, the role and mechanism of circadian rhythm dysfunction is less well understood. In a well-characterized cohort of patients with AD at the mild cognitive impairment stage (MCI-AD), we identify that circadian rhythm irregularities were accompanied by altered humoral immune responses detected in both the cerebrospinal fluid and plasma as well as alterations of cerebrospinal fluid biomarkers of neurodegeneration. On the other hand, sleep disruption was more so associated with abnormalities in circulating markers of immunity and inflammation and decrements in cognition.

scholarly journals Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Philipp Spitzer ◽  
Heinke Schieb ◽  
Heike Kamrowski-Kruck ◽  
Markus Otto ◽  
Davide Chiasserini ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Mitogen Activated Protein Kinase ◽  
Fluid Sample ◽  
Alzheimer Dementia ◽  
Extracellular Signal Regulated Kinase ◽  
Total Tau ◽  
Extracellular Signal ◽  
Mitogen Activated Protein

Cerebrospinal fluid (CSF) samples from 33 patients with Alzheimer dementia (AD), 21 patients with mild cognitive impairment who converted to AD during followup (MCI-AD), 25 patients with stable mild cognitive impairment (MCI-stable), and 16 nondemented subjects (ND) were analyzed with a chemiluminescence immunoassay to assess the levels of the mitogen-activated protein kinase ERK1/2 (extracellular signal-regulated kinase 1/2). The results were evaluated in relation to total Tau (tTau), phosphorylated Tau (pTau), and beta-amyloid 42 peptide (Aβ42). CSF-ERK1/2 was significantly increased in the AD group as compared to stable MCI patients and the ND group. Western blot analysis of a pooled cerebrospinal fluid sample revealed that both isoforms, ERK1 and ERK2, and low amounts of doubly phosphorylated ERK2 were detectable. As a predictive diagnostic AD biomarker, CSF-ERK1/2 was inferior to tTau, pTau, and Aβ42.

[P4-150]: COMORBIDITIES IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT WERE NOT RELATED TO AD PATHOLOGY ACCORDING TO CEREBROSPINAL FLUID BIOMARKERS

2017 ◽  
Vol 13 (7S_Part_27) ◽  
pp. P1315-P1315
Author(s):  
Paulo Renato Canineu ◽  
Florindo Stella ◽  
Marcos Vasconcelos Pais ◽  
Júlia Cunha Loureiro ◽  
Leandro L.C. Valiengo ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cerebrospinal Fluid Biomarkers

scholarly journals Electrophysiological disruptions and cerebrospinal fluid biomarkers in mild cognitive impairment patients

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Brenda Chino Vilca ◽  
Inmaculada Concepción Rodríguez Rojo ◽  
Lucia Torres ◽  
Pablo Cuesta ◽  
Anna Carnes ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cerebrospinal Fluid Biomarkers

[P1-240]: CLINICAL IMPACT OF CEREBROSPINAL FLUID BIOMARKERS IN MILD COGNITIVE IMPAIRMENT DIAGNOSIS

2017 ◽  
Vol 13 (7S_Part_7) ◽  
pp. P336-P337 ◽  
Author(s):  
Emmanuel Cognat ◽  
Anne-Cécile Troussière ◽  
David Wallon ◽  
Julien Dumurgier ◽  
Eloi Magnin ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Impact ◽  
Cerebrospinal Fluid Biomarkers
Sign in / Sign up

Export Citation Format

Share Document