scholarly journals Soy Isoflavones in the Prevention of Menopausal Bone Loss and Menopausal Symptoms

2011 ◽  
Vol 171 (15) ◽  
pp. 1363 ◽  
Author(s):  
Silvina Levis
Keyword(s):  
Bone Loss ◽  
Soy Isoflavones ◽  
Menopausal Symptoms

scholarly journals Soy Isoflavones for the Prevention of Menopausal Symptoms and Bone Loss—A Safe and Effective Alternative to Estrogen?

AAOHN Journal ◽  
2011 ◽  
Vol 59 (11) ◽  
pp. 504-504
Author(s):  
Stephanie Chalupka
Keyword(s):  
Bone Loss ◽  
Soy Isoflavones ◽  
Menopausal Symptoms ◽  
Daily Administration ◽  
Effective Alternative ◽  
Prevent Bone Loss

Daily administration of soy isoflavones for 2 years did not prevent bone loss or menopausal symptoms.

Soy Isoflavones May Protect Against Orchidectomy-Induced Bone Loss in Aged Male Rats

2004 ◽  
Vol 76 (1) ◽  
pp. 56-62 ◽  
Author(s):  
D. A. Khalil ◽  
E. A. Lucas ◽  
B. J. Smith ◽  
D. Y. Soung ◽  
L. Devareddy ◽  
...  
Keyword(s):  
Bone Loss ◽  
Soy Isoflavones ◽  
Male Rats

scholarly journals The Soy Isoflavones for Reducing Bone Loss Study: 3-Yr Effects on pQCT Bone Mineral Density and Strength Measures in Postmenopausal Women

2011 ◽  
Vol 14 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Kristine M. Shedd-Wise ◽  
D. Lee Alekel ◽  
Heike Hofmann ◽  
Kathy B. Hanson ◽  
Dan J. Schiferl ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Soy Isoflavones ◽  
Mineral Density

Soy Isoflavones Mitigate Long-Term Femoral and Lumbar Vertebral Bone Loss in Middle-Aged Ovariectomized Mice

2009 ◽  
Vol 12 (3) ◽  
pp. 536-541 ◽  
Author(s):  
Dae Won Kim ◽  
Ki-Yeon Yoo ◽  
Yoon-Bok Lee ◽  
Keun-Ha Lee ◽  
Heon-Soo Sohn ◽  
...  
Keyword(s):  
Bone Loss ◽  
Soy Isoflavones ◽  
Middle Aged ◽  
Vertebral Bone ◽  
Ovariectomized Mice

scholarly journals The Soy Isoflavones for Reducing Bone Loss (SIRBL) Study: a 3-y randomized controlled trial in postmenopausal women

2009 ◽  
Vol 91 (1) ◽  
pp. 218-230 ◽  
Author(s):  
D Lee Alekel ◽  
Marta D Van Loan ◽  
Kenneth J Koehler ◽  
Laura N Hanson ◽  
Jeanne W Stewart ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Controlled Trial ◽  
Soy Isoflavones ◽  
Randomized Controlled

scholarly journals The Combination of Soy Isoflavones and Resveratrol Preserve Bone Mineral Density in Hindlimb-Unloaded Mice

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2043
Author(s):  
Yuko Tousen ◽  
Ryota Ichimaru ◽  
Takashi Kondo ◽  
Masaki Inada ◽  
Chisato Miyaura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Loss ◽  
Bone Mineral ◽  
Bone Marrow Cells ◽  
Control Diet ◽  
Soy Isoflavones ◽  
Hindlimb Unloading ◽  
Mineral Density ◽  
Expression Ratio ◽  
Positive Balance

It is well known that physical inactivity during space flight or prolonged bed rest causes rapid bone loss. Soy isoflavones (ISOs) and resveratrol (RES) have been reported to be useful to maintain a positive balance for bone turnover. Therefore, we examined the combined effects of ISO and RES on bone loss that was induced by hindlimb-unloading in mice. Female eight-week-old ddY mice were divided into the following six groups (n = 6–8 each): normally housed mice, loading mice, hindlimb-unloading (UL) mice fed a control diet, UL mice fed a 0.16% ISO conjugates, UL mice fed a 0.15% RES diet, and UL mice fed a 0.16% ISO and 0.15% RES diet. After three weeks, femoral bone mineral density was markedly decreased in unloading mice. The combination of ISO and RES prevented bone loss and especially maintained the trabecular bone mineral density more effectively compared with cortical bones. ISO and/or RES inhibited the increase in the RANKL/OPG expression ratio in bone marrow cells in UL mice. These results suggest that the combination of ISO and RES had a preventive effect against bone loss induced by hindlimb-unloading in mice. These osteoprotective effects of ISO and RES may result from the inhibition of bone resorption.

scholarly journals AReview of the Animal Models Used to Investigate the Health Benefits of Soy Isoflavones

2006 ◽  
Vol 89 (4) ◽  
pp. 1215-1228 ◽  
Author(s):  
Gerard M Cooke
Keyword(s):  
Animal Models ◽  
Cognitive Skills ◽  
Cardiovascular Health ◽  
Health Benefits ◽  
Soy Isoflavones ◽  
Menopausal Symptoms ◽  
Blood Cholesterol ◽  
Lipid Lowering ◽  
Original Research ◽  
Cell Degeneration

Abstract This review considers the recent literature in which animal models were used to investigate the purported health benefits of soy isoflavones. The main conclusions are that our animal models demonstrate minimal effects in breast, prostate, and colon cancer prevention, and that, while some cancers may respond to isoflavones, it would appear that isoflavones do not prevent further development once cancer has become established. Regarding cardiovascular health, the lipid-lowering effects of isoflavones have been established, but their efficacy may be less than original research purported. However, it may be considered a bonus of habitual soy consumption that blood cholesterol levels would be reduced somewhat. With respect to osteoporosis and menopausal symptoms, animal models do not show any consistent benefit of isoflavones in preventing osteoporosis, and calcium fortification or the use of prescribed medications are likely much better approaches to combat bone loss. However, our animal models of osteoporosis and menopausal symptoms may not be entirely representative of the human situation. Perhaps the benefit of isoflavones in cognitive skills and in delaying Alzheimer's disease is an area where they can be of some advantage. However, this field is very recent and requires much more research in both humans and animal models before any definitive benefit can be propounded. On the other hand, isoflavones in moderation are probably not dangerous, as few studies have indicated adverse effects. However, large doses have been shown to increase apoptosis and cell degeneration, and in some cancer regimes, once the cancer has progressed beyond the hormone-dependent stage, high doses of isoflavones may be contraindicated. The prospect of mega-dosing from isoflavone supplements opens a new chapter in the risk assessment of isoflavone consumption.

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