scholarly journals Effect of Antihypertensive Therapy on Cognitive Function in Early Executive Cognitive Impairment: A Double-blind Randomized Clinical Trial

2012 ◽  
Vol 172 (5) ◽  
pp. 442 ◽  
Author(s):  
Ihab Hajjar ◽  
Meaghan Hart ◽  
Yu-Ling Chen ◽  
Wendy Mack ◽  
William Milberg ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Randomized Clinical Trial ◽  
Antihypertensive Therapy ◽  
Double Blind

scholarly journals The Efficacy of Mindfulness-Based Alzheimer’s Stimulation (Mbas) in the Progression of Cognitive Impairment: A Double-Blind, Randomized Clinical Trial

2014 ◽  
Vol 4 (2) ◽  
pp. 101-112
Author(s):  
Domingo Jesús Quintana Hernández ◽  
María del Pino Quintana Montesdeoca
Keyword(s):  
Clinical Trial ◽  
Cognitive Impairment ◽  
Randomized Clinical Trial ◽  
Repeated Measures ◽  
Cognitive Stimulation ◽  
Mindfulness Practice ◽  
Controlled Study ◽  
Control Group ◽  
Double Blind ◽  
And Control

We conducted a randomized, controlled study in order to investigate the feasibility, security as well as the effects of the practice of mindfulness upon the evolution of AD. The efficacy of a Mindfulness-based Cognitive Stimulation program for Alzheimer’s patients was tested in this double-blind, randomized clinical trial, using repeated measures of CAMDEX (CAMCOG y MMSE) every six months during two years. A total of 168 patients, presenting a Probable Alzheimer Disease according to NINCDS-ADRDA criteria and treated with donepezil, were randomly assigned to the four following non-pharmacological treatments: standard cognitive stimulation, progressive muscular relaxation, mindfulness-based Alzheimer stimulation and control group, which received no intervention. Each experimental group worked in 90-minute sessions, three times per week during two years (a total of 96 weeks). Results indicated that the Mindfulness-based Alzheimer Stimulation group did not show as much a significant decline of cognitive function as the other groups did. Therefore, it seems that mindfulness practice, as implemented in this program, can have a preventive role against the progression of cognitive impairment in AD. These results support the use of mindfulness as a non-pharmacological treatment.

scholarly journals Effect of Anodal Transcranial Direct Current Stimulation Combined With Cognitive Training for Improving Cognition and Language Among Children With Cerebral Palsy With Cognitive Impairment: A Pilot, Randomized, Controlled, Double-Blind, and Clinical Trial

2021 ◽  
Vol 9 ◽  
Author(s):  
Eun Jae Ko ◽  
Mi Jin Hong ◽  
Eun Jung Choi ◽  
Jin Sook Yuk ◽  
Mi Sun Yum ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cerebral Palsy ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cognitive Training ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Sham Group ◽  
Double Blind ◽  
Randomized Controlled

About 30–45% of cerebral palsy (CP) patients have cognitive impairment. Previous studies showed the evidence that transcranial direct current stimulation (tDCS) may have some benefits in attention-deficit/hyperactivity disorder, autism spectrum disorder, and motor development in CP. The aim of this study is to evaluate the effect of tDCS on cognition, language, and activities of daily living (ADL) among children with CP with cognitive impairment. It was a pilot, randomized, controlled, double-blind, clinical trial in a tertiary pediatric hospital, and 13 children with CP and a cognitive age under 42 months were enrolled. tDCS group (n = 8) had active tDCS and cognitive training (20 min/session, total 20 sessions, for 12 weeks) and sham group (n = 5) had sham tDCS and cognitive training. Primary outcome was the Bayley Scales of Infant Development II (BSID II). Secondary outcomes were the Pediatric Evaluation of Disability Inventory (PEDI), the Laboratory Temperament Assessment Battery (Lab-TAB), the Early Childhood Behavior Questionnaire (ECBQ), the Korean version of MacArthur–Bates Communicative Development Inventories (M-B CDI-K), the Sequenced Language Scale for Infants (SELSI) and the Preschool Receptive-Expressive Language Scale (PRES). After intervention, the tDCS group showed significant improvements in all measurements (p < 0.05) except the M-B CDI-K (grammar), whereas the sham group only showed significant improvements in the Lab-TAB (manipulation domain), the ECBQ (attentional shifting), and the M-B CDI-K (comprehension). The between-group differences in the degree of post-intervention improvement were not statistically significant. The degree of improvement was associated with better baseline cognitive function and younger age (p < 0.05). There were no major adverse events after tDCS. The combined application of tDCS and cognitive training was feasible and associated with improvements in cognitive function, ADL, and language among children with CP with cognitive impairment. However, considering that it is a pilot study, further larger-scale systematic investigation is needed.Clinical Trial Registration: The trial was registered in the Clinical Research Information Service database, identifier: KCT0003023.

scholarly journals The Efficacy of Mindfulness-Based Alzheimer’s Stimulation (Mbas) in the Progression of Cognitive Impairment: A Double-Blind, Randomized Clinical Trial

2014 ◽  
Vol 4 (2) ◽  
pp. 101-112
Author(s):  
Domingo Jesús Quintana Hernández ◽  
María del Pino Quintana Montesdeoca
Keyword(s):  
Clinical Trial ◽  
Cognitive Impairment ◽  
Randomized Clinical Trial ◽  
Repeated Measures ◽  
Cognitive Stimulation ◽  
Mindfulness Practice ◽  
Controlled Study ◽  
Control Group ◽  
Double Blind ◽  
And Control

We conducted a randomized, controlled study in order to investigate the feasibility, security as well as the effects of the practice of mindfulness upon the evolution of AD. The efficacy of a Mindfulness-based Cognitive Stimulation program for Alzheimer’s patients was tested in this double-blind, randomized clinical trial, using repeated measures of CAMDEX (CAMCOG y MMSE) every six months during two years. A total of 168 patients, presenting a Probable Alzheimer Disease according to NINCDS-ADRDA criteria and treated with donepezil, were randomly assigned to the four following non-pharmacological treatments: standard cognitive stimulation, progressive muscular relaxation, mindfulness-based Alzheimer stimulation and control group, which received no intervention. Each experimental group worked in 90-minute sessions, three times per week during two years (a total of 96 weeks). Results indicated that the Mindfulness-based Alzheimer Stimulation group did not show as much a significant decline of cognitive function as the other groups did. Therefore, it seems that mindfulness practice, as implemented in this program, can have a preventive role against the progression of cognitive impairment in AD. These results support the use of mindfulness as a non-pharmacological treatment.

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