Floxacillin-induced cholestatic hepatitis with evidence of lymphocyte sensitization

1987 ◽  
Vol 147 (5) ◽  
pp. 987-989 ◽  
Author(s):  
R. M. Victorino
Keyword(s):  
Cholestatic Hepatitis ◽  
Lymphocyte Sensitization

Fibrosing cholestatic hepatitis: Clinical features, outcome and response to interferon and ribavirin

2001 ◽  
Vol 120 (5) ◽  
pp. A563-A564
Author(s):  
M ISMAIL ◽  
I DABOUL ◽  
B WATERS ◽  
J FLECKENSTEIN ◽  
S VERA ◽  
...  
Keyword(s):  
Clinical Features ◽  
Cholestatic Hepatitis

A case of acute cholestatic hepatitis induced by Corydalis speciosa Max

2009 ◽  
Vol 15 (4) ◽  
pp. 517 ◽  
Author(s):  
Hyun Seok Kang ◽  
Hyuk Soon Choi ◽  
Tae Jung Yun ◽  
Kwang Gyun Lee ◽  
Yeon Seok Seo ◽  
...  
Keyword(s):  
Cholestatic Hepatitis

Amoxicillin-Clavulanic Acid Induced Cholestatic Hepatitis: a Case Report

Drug Safety ◽  
2006 ◽  
Vol 29 (10) ◽  
pp. 911-1010
Author(s):  
H. Ghozzi ◽  
B. Hammami ◽  
H. Affes ◽  
S. Hammami ◽  
L. Ayedi ◽  
...  
Keyword(s):  
Case Report ◽  
Clavulanic Acid ◽  
Hepatitis A ◽  
Cholestatic Hepatitis ◽  
Amoxicillin Clavulanic Acid

High-level expression of hepatitis B viral antigens in fibrosing cholestatic hepatitis

1992 ◽  
Vol 102 (3) ◽  
pp. 956-962 ◽  
Author(s):  
Johnson Y.N. Lau ◽  
Vincent G. Bain ◽  
Susan E. Davies ◽  
John G. O'Grady ◽  
Alfredo Alberti ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Cholestatic Hepatitis ◽  
High Level Expression ◽  
Viral Antigens ◽  
High Level

Liver disease with altered bile acid transport in Niemann-Pick C mice on a high-fat, 1% cholesterol diet

2005 ◽  
Vol 289 (2) ◽  
pp. G300-G307 ◽  
Author(s):  
Robert P. Erickson ◽  
Achyut Bhattacharyya ◽  
Robert J. Hunter ◽  
Randall A. Heidenreich ◽  
Nathan J. Cherrington
Keyword(s):  
Liver Disease ◽  
Bile Acid ◽  
High Fat Diet ◽  
Density Lipoprotein ◽  
Cholestatic Hepatitis ◽  
Diffuse Fibrosis ◽  
Acid Transport ◽  
High Fat ◽  
Bile Acid Transport ◽  
Niemann Pick

Cholestatic hepatitis is frequently found in Niemann-Pick C (NPC) disease. We studied the influence of diet and the low density lipoprotein receptor (LDLR, Ldlr in mice, known to be the source of most of the stored cholesterol) on liver disease in the mouse model of NPC. Npc1−/− mice of both sexes, with or without the Ldlr knockout, were fed a 18% fat, 1% cholesterol (“high-fat”) diet and were evaluated by chemical and histological methods. Bile acid transporters [multidrug resistance protein (Mrps) 1–5; Ntcp, Bsep, and OatP1, 2, and 4] were quantitated by real-time RT-PCR. Many mice died prematurely (within 6 wk) with hepatomegaly. Histopathology showed an increase in macrophage and hepatocyte lipids independent of Ldlr genotype. Non-zone-dependent diffuse fibrosis was found in the surviving mice. Serum alanine aminotransferase was elevated in Npc1−/− mice on the regular diet and frequently became markedly elevated with the high-fat diet. Serum cholesterol was increased in the controls but not the Npc1−/− mice on the high-fat diet; it was massively increased in the Ldlr−/− mice. Esterified cholesterol was greatly increased by the high-fat diet, independent of Ldlr genotype. γ-Glutamyltransferase was also elevated in Npc1−/− mice, more so on the high-fat diet. Mrps 1–5 were elevated in Npc1−/− liver and became more elevated with the high-fat diet; Ntcp, Bsep, and OatP2 were elevated in Npc1−/− liver and were suppressed by the high-fat diet. In conclusion, Npc1−/− mice on a high-fat diet provide an animal model of NPC cholestatic hepatitis and indicate a role for altered bile acid transport in its pathogenesis.

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