Effects of sickle cell anemia on conjunctival oxygen tension and temperature

1987 ◽  
Vol 147 (1) ◽  
pp. 67-69 ◽  
Author(s):  
S. J. Isenberg
Keyword(s):  
Oxygen Tension ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Conjunctival Oxygen Tension

The orientation of sickle hemoglobin fibers within fascicles

1988 ◽  
Vol 46 ◽  
pp. 400-401
Author(s):  
Christopher A. Miller ◽  
Bridget Carragher ◽  
William A. McDade ◽  
Robert Josephs
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Relative Orientation ◽  
Unit Cell ◽  
Red Cell ◽  
High Ph ◽  
Sickle Hemoglobin ◽  
Polar Crystal ◽  
Helical Configuration

Highly ordered bundles of deoxyhemoglobin S (HbS) fibers, termed fascicles, are intermediates in the high pH crystallization pathway of HbS. These fibers consist of 7 Wishner-Love double strands in a helical configuration. Since each double strand has a polarity, the odd number of double strands in the fiber imparts a net polarity to the structure. HbS crystals have a unit cell containing two double strands, one of each polarity, resulting in a net polarity of zero. Therefore a rearrangement of the double strands must occur to form a non-polar crystal from the polar fibers. To determine the role of fascicles as an intermediate in the crystallization pathway it is important to understand the relative orientation of fibers within fascicles. Furthermore, an understanding of fascicle structure may have implications for the design of potential sickling inhibitors, since it is bundles of fibers which cause the red cell distortion responsible for the vaso-occlusive complications characteristic of sickle cell anemia.

Abstract #914: Polyglandular Autoimmune Syndrome in a Patient with Sickle Cell Anemia and Iron Overload

2005 ◽  
Vol 11 ◽  
pp. 85
Author(s):  
Allison Elise Kerr ◽  
Wolali Odonkor ◽  
Gail Nunlee-Bland ◽  
Juanita Archer ◽  
Anitha Kolukula ◽  
...  
Keyword(s):  
Iron Overload ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Polyglandular Autoimmune Syndrome ◽  
Autoimmune Syndrome

Sickle cell anemia 1910-1973. An overview

1974 ◽  
Vol 133 (4) ◽  
pp. 529-532 ◽  
Author(s):  
L. S. Lessin
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia

Leg ulceration in sickle cell anemia

1974 ◽  
Vol 133 (4) ◽  
pp. 690-694 ◽  
Author(s):  
G. R. Serjeant
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia
Sign in / Sign up

Export Citation Format

Share Document