Heinz body hemolytic animea. "Bite cells" -a clue to diagnosis

1976 ◽  
Vol 136 (2) ◽  
pp. 153-155 ◽  
Author(s):  
M. S. Greenberg
Keyword(s):  
Heinz Body

Letter: Heinz body hemolytic anemia

1976 ◽  
Vol 136 (9) ◽  
pp. 1067a-1067
Author(s):  
E. P. Gabor
Keyword(s):  
Hemolytic Anemia ◽  
Heinz Body

Heinz-Body Anaemia in the Newborn

PEDIATRICS ◽  
1957 ◽  
Vol 19 (6) ◽  
pp. 1001-1001
Keyword(s):  
Hemolytic Anemia ◽  
Case Reports ◽  
Newborn Infants ◽  
Term Infant ◽  
Heinz Bodies ◽  
Heinz Body ◽  
Large Numbers ◽  
Complete Reversal ◽  
Staining Techniques ◽  
Supravital Staining

The association of Heinz-bodies within erythrocytes, extreme distortion of the size and shape of erythrocytes and hemolytic anemia in newborn infants, especially premature infants, has been sporadically reported in the medical literature since 1948. Heinz-bodies are thought to be either remnants of disintegrated membranes of erythocytes or abnormal products of hemoglobin metablism, and are demonstrable only by supravital staining techniques. The present study contributes two case reports and discusses the sequence of the clinical and hematologic manifestations. The first patient was a full-term infant who developed jaundice and symptoms attributable to anemia at 2 weeks of life. The second infant was prematurely born, did not develop jaundice but showed large numbers of Heinz-bodies (70%) as the anemia progressed. Both patients responded well to a single transfusion of packed blood cells, with complete reversal of the abnormal peripheral blood findings. None of the usual causes of hemolysis could be demonstrated by extensive laboratory tests. Agents such as phenylhydrazine, known to produce Heinz-bodies, could not be incriminated. The phenomenon of Heinz-body formation in infants may be more common than is apparent as the technique of demonstration is not commonly a part of the routine study of infants with evidence of hemolytic anemia. This technique is described and illustrations of erythrocytes containing Heinz-bodies are provided.

Congenital Heinz-Body Anaemia.

1964 ◽  
Vol 10 (3) ◽  
pp. 281-290 ◽  
Author(s):  
A. J. Grimes ◽  
A. Meisler ◽  
J. V. Dacie
Keyword(s):  
Heinz Body

Heinz-body Anaemia Due to Dapsone

BMJ ◽  
1959 ◽  
Vol 1 (5127) ◽  
pp. 970-971
Author(s):  
M. Skogh
Keyword(s):  
Heinz Body

Hereditary Heinz-Body Anaemia.

1964 ◽  
Vol 10 (3) ◽  
pp. 388-402 ◽  
Author(s):  
J. V. Dacie ◽  
A. J. Grimes ◽  
A. Meisler ◽  
L. Steingold ◽  
E. H. Hemsted ◽  
...  
Keyword(s):  
Heinz Body

Post-parturient haemoglobinuria in cattle: A Heinz body haemolytic anaemia

1971 ◽  
Vol 19 (11) ◽  
pp. 259-263 ◽  
Author(s):  
D. Martinovich ◽  
D.A. Woodhouse
Keyword(s):  
Haemolytic Anaemia ◽  
Heinz Body

Heinz-body anemia: “Bite Cell” variant— A light and electron microscopic study

1983 ◽  
Vol 15 (2) ◽  
pp. 135-146 ◽  
Author(s):  
Patrick C. J. Ward ◽  
Burton S. Schwartz ◽  
James G. White
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Electron Microscopic ◽  
Heinz Body ◽  
Cell Variant

Spurious, marked leukocytosis in 2 cats with Heinz body hemolytic anemia

2020 ◽  
Vol 49 (2) ◽  
pp. 232-239
Author(s):  
Courtney E. Johnson ◽  
Davis M. Seelig ◽  
Frances M. Moore ◽  
Tammy J. Ruska ◽  
Daniel A. Heinrich
Keyword(s):  
Hemolytic Anemia ◽  
Heinz Body

scholarly journals Elevated glutathione accelerates oxidative damage to erythrocytes produced by aromatic disulfide

Blood ◽  
1989 ◽  
Vol 73 (1) ◽  
pp. 312-317 ◽  
Author(s):  
Y Maede ◽  
M Kuwabara ◽  
A Sasaki ◽  
M Inaba ◽  
W Hiraoka
Keyword(s):  
Electron Spin Resonance ◽  
Oxidative Damage ◽  
Electron Spin ◽  
Normal Level ◽  
Reduced Glutathione ◽  
Spin Trapping ◽  
High Concentration ◽  
Heinz Body ◽  
Spin Resonance ◽  
Body Count

Abstract It has been shown that certain dogs have erythrocytes characterized by an inherited high concentration of reduced glutathione (GSH), five to seven times the normal level (high-GSH RBCs). We examined whether increased GSH in dog erythrocytes leads to increased protection against oxidative damage induced by acetylphenylhydrazine (APH) and/or 4- aminophenyl disulfide (4-AD). When erythrocytes were incubated with 30 mmol/L APH, the Heinz body count was appreciably higher in normal RBCs than in high-GSH RBCs, while there was no difference in the increase of the methemoglobin (metHb) concentration in both RBCs. In contrast, both the Heinz body count and metHb production were much higher in high-GSH RBCs than in normal RBCs when erythrocytes were incubated with 4-AD. Furthermore, the generation of the superoxide in erythrocytes treated with 4-AD, which was measured by spin trapping combined with electron spin resonance (ESR), was obviously higher in high-GSH RBCs than in normal RBCs. These results clearly indicate that erythrocyte GSH is an important defense against oxidative damage induced by certain compounds such as APH, but that, in contrast, elevated GSH appears to accelerate oxidative damage to erythrocytes produced by aromatic disulfides, such as 4-AD, which generated a superoxide in erythrocytes via its redox reaction with GSH.

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