Leukonychia totalis, multiple sebaceous cysts, and renal calculi. A syndrome

Background: Mutrashmari is a stone like structure anywhere in the Mutravaha Srothas which can be compared with renal calculi and one among the Astamahagada, clinical features as renal angle pain, haematuria, pyuria and dysuria. Peak age is 3rd to 5th decade while majority of patients report regarding onset of disease in 2nd decade of life and male to female ratio is 3:1. Objectives: To compare the effect of Gokshura Churna over Tilanalakshara Yoga in the management of Mutrashmari with special reference to Renal calculi. Materials and Methods: 30 patients were selected on the basis of inclusion criteria and divided into 2 groups with 15 patients in each group by chit method. Group A was treated with standard drug Tilanalakshara Yoga and Group B was traeted with trial drug Gokshura Churna. Results: It was found that standard group reduced the abdominal pain by 85.1%, dysuria by 89.4%, renal angle tenderness 88.4%, haematuria 100%, pyuria 100%, size of renal calculus 41.9% by 21st day of treatment. In study group it was observed that abdominal pain reduced by 92%, dysuria 96.1%, renal angle tenderness 91.6%, haematuria 100%, pyuria 100% and size of renal calculus 48.5% by 21st day of treatment. Conclusion: This assessment showed Gokshura Churna had significant result over Tilanala Kshara Yoga in both subjective and objective parameters with P value less than 0.0001.

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A Case of Renal Calculi

Journal of the Royal Society of Medicine ◽

10.1177/095952877405700107 ◽

1874 ◽

Vol MCT-57 (1) ◽

pp. 77-80

Author(s):

Samuel Gee

Keyword(s):

Renal Calculi

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Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I

Advances in Laboratory Medicine / Avances en Medicina de Laboratorio ◽

10.1515/almed-2021-0018 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Cristina Collazo Abal ◽

Susana Romero Santos ◽

Carmen González Mao ◽

Emilio C. Pazos Lago ◽

Francisco Barros Angueira ◽

...

Keyword(s):

Aldehyde Oxidase ◽

Renal Calculi ◽

Xanthine Dehydrogenase ◽

Type I ◽

Dietary Recommendations ◽

New Mutation ◽

Case Presentation ◽

Hereditary Xanthinuria ◽

Urine Levels ◽

Made In

Abstract Objectives Hereditary xanthinuria is a rare, autosomal and recessive disorder characterized by severe hypouricemia and increased xanthine excretion, caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO, EC: 1.17.1.4/1.17.3.2) in type I, or by a deficiency of XDH/XO and aldehyde oxidase (AOX, EC: 1.2.3.1) in type II. Case presentation We describe a novel point mutation in the XDH gene in homozygosis found in a patient with very low serum and urine levels of uric acid, together with xanthinuria. He was asymptomatic but renal calculi were discovered during imaging. Additional cases were found in his family and dietary recommendations were made in order to prevent further complications. Conclusions Hereditary xanthinuria is an underdiagnosed pathology, often found in a routine analysis that shows hypouricemia. It is important for Laboratory Medicine to acknowledge how to guide clinicians in the diagnosis.

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