Tumor angiogenic factor and human skin tumors

It has been documented in the literature that a solid tumor survives by the generation of micro-vessels around it. This phenomenon is known as angiogenesis. Angiogenesis is governed by two factors, namely Tumor Angiogenic Factor (TAF) secreted by the tumor cells and tissue Fibronectin (FNT) concentration in the extra-cellular space. These two factors help in mobilization of endothelial cells from nearby blood vessels. At the initial phase of angiogenesis, neighboring blood vessels affect in formation of capillary sprouts. In this work, to the authors develop a clinically relevant analytical model that could act as an effective tracing system of tumor growth. The author has performed a quantitative assessment of tumor angiogenesis. This analytical method is a correlation between tumor system and vasculature system through an analytical assessment at peripheral blood circulatory of tumor milieu.

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The method of lines for the numerical solution of a mathematical model for capillary formation: The role of tumor angiogenic factor in the extra-cellular matrix

Applied Mathematics and Computation ◽

10.1016/j.amc.2006.08.021 ◽

2007 ◽

Vol 186 (1) ◽

pp. 891-897 ◽

Cited By ~ 2

Author(s):

Arzu Erdem ◽

Serdal Pamuk

Keyword(s):

Mathematical Model ◽

Numerical Solution ◽

Method Of Lines ◽

Extra Cellular Matrix ◽

Angiogenic Factor ◽

Capillary Formation ◽

The Method Of Lines ◽

Tumor Angiogenic Factor ◽

Cellular Matrix

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The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinoma

Journal of Surgical Research ◽

10.1016/j.jss.2014.11.002 ◽

2015 ◽

Vol 197 (2) ◽

pp. 219-224 ◽

Cited By ~ 8

Author(s):

Lindsay L. Hollander ◽

Xiaojia Guo ◽

Ronald R. Salem ◽

Charles H. Cha

Keyword(s):

Pancreatic Adenocarcinoma ◽

Angiogenic Factor ◽

The Novel ◽

Tumor Angiogenic Factor

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The BamHI Restriction Fragment Length Polymorphism Detected in the c-Ha-ras Locus of Human Skin Tumors

The Journal of Dermatology ◽

10.1111/j.1346-8138.1988.tb03666.x ◽

1988 ◽

Vol 15 (2) ◽

pp. 141-148 ◽

Cited By ~ 1

Author(s):

Minoru Murayama ◽

Takashi Mita ◽

Yoshinori Suenaga ◽

Kazukata Nishio

Keyword(s):

Restriction Fragment Length Polymorphism ◽

Human Skin ◽

Restriction Fragment ◽

Length Polymorphism ◽

Fragment Length ◽

Fragment Length Polymorphism ◽

Skin Tumors ◽

Restriction Fragment Length

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The Distribution of the Desmosomal Protein, Plakophilin 1, in Human Skin and Skin Tumors

Journal of Investigative Dermatology ◽

10.1111/1523-1747.ep12332388 ◽

1997 ◽

Vol 108 (2) ◽

pp. 139-146 ◽

Cited By ~ 62

Author(s):

Ingrid Moll ◽

Hjalmar Kurzen ◽

Lutz Langbein ◽

Werner W. Franke

Keyword(s):

Human Skin ◽

Skin Tumors ◽

Desmosomal Protein

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Multiple Roles for VEGF in Non-Melanoma Skin Cancer: Angiogenesis and Beyond

Journal of Skin Cancer ◽

10.1155/2012/483439 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 27

Author(s):

Kelly E. Johnson ◽

Traci A. Wilgus

Keyword(s):

Skin Cancer ◽

Critical Role ◽

Tumor Development ◽

Skin Carcinogenesis ◽

Skin Tumors ◽

Angiogenic Factor ◽

Non Melanoma Skin Cancer ◽

New Treatments ◽

Melanoma Skin

Vascular endothelial growth factor (VEGF) is known to play a critical role in the development of non-melanoma skin cancers. VEGF is a potent pro-angiogenic factor and it is elevated in mouse and human skin tumors. The use of transgenic and knockout mice has shown that VEGF is essential for tumor development in multiple models of skin carcinogenesis and, until recently, the mechanism of action has been primarily attributed to the induction of angiogenesis. However, additional roles for VEGF have now been discovered. Keratinocytes can respond directly to VEGF, which could influence skin carcinogenesis by altering proliferation, survival, and stemness.In vivostudies have shown that loss of epidermal VEGFR-1 or neuropillin-1 inhibits carcinogenesis, indicating that VEGF can directly affect tumor cells. Additionally, VEGF has been shown to promote tumor growth by recruiting macrophages to skin tumors, which likely occurs through VEGFR-1. Overall, these new studies show that VEGF carries out functions beyond its well-established effects on angiogenesis and highlight the need to consider these alternative activities when developing new treatments for non-melanoma skin cancer.

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